Am I in the right headspace?
Do I travel the galaxies conjured by my thoughts just to end up in black holes?
I’m seeking epiphanies
You know, those elusive supernovas that defy even the eyes of gods
I claim to be rich in spirit, yes
Trying to measure my wealth with the hours I spend in the stratosphere
above every worry that injects my bones with the weight of 2 Earths-
the weight of a place that doesn’t want to ever wait
Yet it must
You can’t break a chrysalis and expect patterns on the wings
You’ll get misshapen kaleidoscopes
and fragmented isotopes
beings who’ve never climbed but will die trying to ascend ropes
Am I in the right headspace?
Is my consciousness a constellation waiting to take form?
What will be the shape?
I’ll never be strong enough to resemble the buckle on Orion’s belt
I’ll never be the mouth at the big dipper,
drunk on the secrets of the cosmos
I’d want to be the hands gripping Polaris
sharing light for the planets who only see a moon rise
Am I in the right headspace?
Because I’ve fallen into nebulas,
realms where humans stand on the heads of giants yet look no higher
I’ve seen flawed ideologies that challenge monuments with their size
I wonder what it’d take for us to realize that we could be immortals
free from the finite mentalities that stunt our growth from the very roots.

Get out of my headspace ...
It's too clouded.
I'm no longer able to decipher the view outside ,
my eyes are no longer a window,
the brain just a sham of the thoughts once creatively flowed.
A raging storm within.
How long will this go on?
days ? weeks? months? years?
or perhaps maybe even an eternity?
It's a blizzard unfit for humanity ,
my deepest innermost thoughts are frozen solid ,
no longer spirits they once were,
you need to leave.
This headspace of mine cannot bare it any longer.
It may spread to my body.
The cold is numbing,
dehabiliting to the mind.
Imagine what it could do to my body,
halt all movement,
solidify the blood in every vain,
creating a state of frozen paralysis.
The only outcome is death.
Please leave my headspace.
You are no longer welcome.
These chills down my spine are a foreshadowing of the destruction to come to my temple.

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

Finally
remembering
how
to
forget.

the brain and mind are not the same thing.

a brain floats, suspended,
down to the tips of my toes
and the blue rivers underneath my skin.

it is a box; simple tasks and quiet construction.

the mind has no such manuals.

it sees baboons in filtered skylights,
eyes as red as the blushing dawn,
gushing about over the hilltops of my shoulders.

it sees stop signs in the glass cracks
of my wooden closet door,
where the dark seeps around the green-light-go.

it sees fingertip to lip,
raccoons at rusty roadways,
Remus and Romulus locked in eternal combat;
preserved in the grains in the cherry tree trunk.

the brain is in the head,
but the mind is somewhere a little above;

hiding away in a doomsday bunker,
loud warnings burning the air,
bathed in cobwebs and blue lights.

away from people who haven’t quite learned,

that the brain and mind are not the same thing.

Pad and pen,
here are Casey’s thoughts again...

Driving down the highway, Jason is strapped in because Casey’s in denial again. She doesn’t want to lose her little one.

Wake up Casey, you’re dreaming. He’s gone.
You drove under the influence.
What’s wrong with you?  
This is what you get. He’s never coming back.

Driving silent like a mime with its mouth sewn shut.
You’re just like a mime, living in a black and white world.
You’re gray matter Case.
You’re a nut-case.
Where’d you put your straight jacket?

You hit your brakes to assure Jason will be safe.
Convinced that at every intersection there’s a conspiracy against you,
sure to get hit.

But Casey, it’s too late. This is what you get.
He’s never coming back.

Why’d you have to reach for more?



Lock her up.
Strap her in.

Casey's off the deep end... again.

I often dream of running, I dream of fleeing
but every time I try to leave
they drag me back to this place they’ve deemed
reality.

I often find I’m lost in their uncertainty –
but I'm certain that I’m dying
in this place that I was never meant to
be.

That thing she did. It was so innocuous, so accidental, so minor, yet it awakened you. It consumes your headspace. Follows you through hours and days. Makes appearances in your dreams, kissing the edges of your mind. Because of it, you know what it feels like to want someone so much you grow a second heart. Such a gesture should be easily forgotten, but you can’t forget the belly-rolling starburst of it, the oh. That thing she did, it told you who you are. In one split-second act. It grabbed you by the collar, looked you in the eye, and said her. It’s her. Are you brave enough to listen?

2. You want to feign your own fall just so she will lean over you, blocking the sky, beautiful and concentrated. So she will hold your wrist and feel for your rabbit pulse. So you can blink up at her with an excuse for not looking away.

3. She’s sitting there sketching a tree in the margin of her notebook, and she is a miracle. You would die for her. The thought startles you. You want to kiss her, want it savagely, which startles you, too. Your hands stay balled in your lap, half-clenched and trembling.

4. You move and it’s just enough to push the two of you together. Which is, god, the best thing you have ever felt. She draws her eyes toward you with the soft look that takes you out every time. Her arm is pressing yours, solid and warm. You flush and can’t understand why, but you should. That blush knows everything you haven’t yet figured out.

5. You watch her when she leaves, always. You can’t help it. She’s furiously lovely, so much your chest is sore at the sight of her. She hurts you, this girl. She moves you.