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To boldly go where no mind has gone before.

We are soul-sailors,
Navigators of the spirit.

In altered states of awareness
we will explore consciousness
to the limits of our understanding
and beyond.
We know not
What we might find.

Were existence a sandbox
and the psyche, our playground.

We charter the ever-renewing realms of mind
in our perpetual journey
to define this phenomenal life. The true psychonaut
can weather Absurdus, accept it
and venture on.

Life is chemical;
Welcome to The Entheon:

In transcendention we become
champions of the empyrean.
Our purpose is entheos,
For in our very being
the greatest of discoveries will be made.

We would travel to the hallowed temples of beyond,
A metaphysical pilgrimage (some with use of the compounds).
Our places of worship have no words, we name them:
The Empathion,
The Psychedelion
;
We pray to them, with them, in them.
They are processes, places within which we can comprehend,
A modulation of mental activity, configurations of mind.

Please remember these two things: choice and ceremony.
Dedicated to Shura & Alice Borodin.
All observation is from a particular point, but
acknowledged subjectivity's better than naught.
Thus follows some comments on their qualitative nature.
Use them as you deem. In this piece everything is as it seems.

Caffeine is unappreciated enough,
Give credit to that stimulant for the things it does.
Coffee has little time to play, for there are errands
to attend to before the light fades.

The amphetamine will spin you until you're spun,
The cathinone will also try you with its luck.
The stimulant is a trickster [touch within]
and a magician never reveals their secret,
Even when seeking it befalls endlessness.

Me and E(cstasy) used to dance all night,
Closer to all your dreams was as far
from the light, we soaked ourselves
in emotionality and I soared high:
Perfection in the dark
rekindled my heart
; 'cause
on pills you love everyone.

******* is always hungry but will never feed you
for it is naught but the scent of pure ego;
because on coke everyone loves you.

There is nothing to learn from an opioid or benzodiazepine
beyond the hedonistic stupor in-between awake and sleeping.
Similarly, cigarettes never taught me anything about myself
much like quick, ***** ***, that's nicotine and painkillers, in essence.

Alcohol is reliable for those sociable
but can hurt the body and scorn the emotional.
Drink toyed with me, then she abandoned me;
Despite that messiness I still reminisce occasionally.

Gamma-HydroxyButyric acid [GHB] requires utmost caution,
One must observe the proper conduct when
wading through such subtle intoxication.

Don't use ket too much, don't use angel dust.
If you want a supreme arylcyclohexylamine
seek out methoxetamine, use it responsibly.
Dissociation, end of line; no[thing is o]ne.

Always be considerate before transcending reality,
Reverence for psychedelics keeps them self-regulatory.
Of all the compounds they would humble and reveal to you;
Existential, being when tripping; every[is]one.

Cannabis I dared to use recreationally
for it often reminded us when one should act sensibly.
That deep conversing with trusted friends
is better than any substance I have ever had the nerve to test
.
I was seeking to be lost,
In that journey I found myself
and composed this journal from said
I thought it right to assess some antidepressants, which philosophers should be more inclined to call mood enhancers.
(This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.)

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect. I therefore approached them with the notion that a limited dosage might point to their character which would further manifest in the long-term. (Side-effect were this unlikely to be fully manifest.) These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin reuptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavour of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, intresting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I correctly surmised it has a high affinity for 5-HT2C but was also surprised to find it is is quite adrenergic.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically intresting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energising yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires utmost caution.

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan), indications of a mild serotonin syndrome later became apparent. Symptoms included feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

— The End —