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I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.
RAJ NANDY Jun 2016
Dear Friends, I had composed this poem in 2008 after reading an
article by a Lady Doctor who was a Biologist, and had initially posted it on 'Poemhunter.com'. Hope you will like it! Thanks, - Raj

PHYSICS AND CHEMISTRY OF LOVE !
Love’s physics and chemistry, has forever
remained a mystery!
There are no permanent equations to resolve,
Love's unseen wave like force!
It travels through three dimensional space,
At frequencies higher than electromagnetic
waves!
It remains unhindered by barriers of cast, creed,
or clime,
Giving two beating hearts a feel of the divine!
It generates a magnetic force field, making
two hearts in unison beat!
Yet Biologists claim that a chemical called
(PEA) Phenylethylamine, -
Triggers loves molecules in the human mind!
Chocolates are rich in this PEA content they say,
And is a perfect gift on the Valentine’s Day!
The chemical Dopamine makes the lovers to
glow and feel fine,
When they live on love and fresh air and may
even forget to dine!
While Norepinephrine, which stimulates our
adrenaline production,
Makes the lovers world go round in a joyous
motion!
But Oxytoxin that 'cuddling chemical',  requires
constant contact for its effects to prevail!
Cupid’s arrows may be dipped in its pail,
Before those arrows on lovers begin to hail!
Creating unbearable attraction leading to infatuation,
Making two hearts beat as one with love’s magic
potion!
But such feelings remain for a limited duration,
Varying with people with different emotions!
In a 'mercurial type' loves ecstasy gets mixed, -
And they frequently require a PEA fix!
But those who stick to a single mate,
Are said to be rich in Vasopressin content!
And finally when infatuation gradually subsides,
Chemicals triggered by Endorphine slowly overtakes,
When calmness and stability with loving bond
prevails!
This Endorphine is reputed to be rather addictive,
And firmly binds those forces released by PEA, -
which are rather seductive!
(All Copyrights with Raj Nandy of New Delhi)
The chemicals mentioned in the poem have been verified by Medical Science.
Zak Ridge May 2010
I find it hard to sleep
I find it hard to eat
I find it hard to think
I find it hard to speak
I wonder is this love
Or the use of a Serotonin–norepinephrine reuptake inhibitor?
bobby burns Feb 2015
in the somatic nervous system,
acetylcholine (ACh) stimulates skeletal muscle, causing contraction

action potentials
in the 8am physio lecture,
the biggest on campus
crammed with nursing majors,
and health science hankerers,
public health preachers,
OT saints and angels

amino acid NTs: glutamate (+) GABA (-) aspartate (+) glycine (-)

the prof wrote on a distant whiteboard
too many complained about being lost
she made a joke about feeding *******
to mice for her neuroscience research

amines: serotonin (-) dopamine (-/+) norepinephrine (+/-) epinephrine (+)

STEM-dominated
when i'm just looking
to drop my roots
and press that
good earth into
the spaces between
my toes and
under my nails

but the grounds are a garden
of biodiversity from clippings
gathered by migrant habit-clad
founders more than a century ago

the soil is fertile            it is temperate
there are water filters in most residences

there is enough here for me
*(+) stimulatory (-) inhibitory (+/-) stimulatory or inhibitory depending on the type of receptor to which it binds.

there are two types of summation: spatial and temporal.

in spatial summation, many presynaptic neurons fire to a singular postsynaptic neuron.
in temporal summation, a single presynaptic neuron fires sequentially to a postsynaptic neuron.
At this precise moment.
I'm nothing but a human being under the intense influence of dopamine, norepinephrine, epinephrine and testosterone.
The infuriating effects will last, as will my aggression.

There's a reason why this is all happening. You.
Because of you.
I have no hatred nor much of the love I had for you.
For you have taken that away from me, and given it to him.

I have no words for you.
All the best.
I'm beyond hurt at this precise moment, and I have held this is for too long. To this day I am still unable to let this out. I hate it.
zebra Nov 2021
I've been reading a lot of nonsense about ****** objectification, like objectification is some kind of moral transgression. It's not, unless you want to indict others and yourself for thought crimes.
The term objectification is unfortunately mistaken as a stand in for ****** exploitation. 
 
 Objectification, for some, makes us feel attractive and desired, that we are beautiful, that we attract love and admiration, that we are recognized for our magnetism by strangers. That's certainly one of the motives for working out, watching the waistline and dressing well. 
For others it is about the understandable resistance of an unwanted approach, gaze, or suggestive body language, and while it may create within us a feeling of resistance, it is inherent in the human drama that has always been a part of us and, of course, these two experiences are not mutually exclusive.
But one thing objectification is not, is ****, manhandling, or ****** exploitation. We are all human beings, irrespective of our gender, ****** preferences or ****** sensibilities, with a commonality of desires for love and passion, and while we need to respect each other, we also don't do ourselves and others any favors by being to distressed or rabid about feeling another's heat for us.
Many of us are a great swooning web that wants to swallow and be swallowed in lust and love in search of a special someone, a kind of pre-objectification, for the purpose of future recognition.
****** OBJECTIFICATION is described as "the act of treating a person solely as an object of ****** desire". Objectification more broadly means treating a person as a commodity or an object, without regard to their personality or dignity:  sometimes referred to as "the zipless ****", a phrase coined by Erica Jong in the book "Fear of Flying". As described by her: -"It is a ****** encounter between strangers that has the swift compression of a dream and is seemingly free of all remorse and guilt. It is absolutely pure, there is no power game and it is free of ulterior motives". It has also been described as the perfect one night stand.
She cumed like a cinematic hissing pillow of flames
 
 The point of confusion is that the concept of objectification is mistaken for exploitation, and while sometimes associated, they are radically distinct from one another. Objectification is a DNA-driven biochemical prime directive to create .
Wetter than an otters pocket
 
****** EXPLOITATION: is a crime, meaning taking ****** advantage of another person without effective consent, and includes, without limitation, causing or attempting to cause the incapacitation of another person in order to gain a ****** advantage over such other person; causing the prostitution, or trafficking of another person; recording, photographing or transmitting identifiable images of private ****** activity or knowingly and intentionally exposing another person to a significant risk of a sexually transmitted infection.
OBJECTIFICATION: 
When we find another attractive, the brain has a tendency to flip out in a kind of eclipse as in a black out, like an electrical short perhaps, causing physical symptoms like heart rate increase, asinine nervous talking, sweaty palms, dry mouth, jumpy stomach, hot flashes, or more broadly speaking in a confused gibberish inspired by a spectacular entrancement of obsessive haywire desire. Objectification is the first door we walk though when we recognize our desire for another.
HYPOTHALMUS: part of the brain plays a masterful role in this, stimulating the production of the *** hormones testosterone and estrogen from the ****** and ovaries While these chemicals are often stereotyped as being "male" and "female," respectively, both play a role in men and women. As it turns out, testosterone increases libido in just about everyone. The effects are less pronounced with estrogen, but some women report being more sexually motivated around the time they ovulate, when estrogen levels are highest, which is why men tend to be more sexually aggressive. Women who are introduced to Testosterone for the purpose of body-building or gender change are often astonished by the huge uptick of libidonous desire.
Eeeeek, I could eat you like cherry pie !!!!!
"According to a team of scientists led by Dr. Helen Fisher at Rutgers, desire is broken down into three categories: lust, attraction, and attachment. Each one of these attributes is characterized by its own set of hormones activated by the brain"
LUST… Is driven primarily by Testosterone and Estrogen
ATTRTACTION… dopamine, norepinephrine, and serotonin motivate attraction
ATTACHMENT… oxytocin and vasopressin mediate attachment.
LOVE…When combined these three take us from us from pure objectification to the wholly trinity of love. ~~~~~
ARE YOU OBJECTIFYING ME
are you objectifying me?
i can bench 300 lbs. ten times
I'm a rich artist with a graduate degree
sun tanned
good teeth
driving a new BMW six series
with a rag top
big keen blue eyes
like a pretty girl
wavy hair
smooth *****
seven inch *****
nice ***
with the tender heart of a poet 
and a square jaw
want to wine and dine you
always smiling
bay *** kisses
silky tee shirts
Hawaiian 
luau vacations
or is it off to my castle 
in the 
Carpathians
impeccable manners
i smell like lavender coconut butter cream
live in a grand house
on 
beach front property
mucho bucks in the bank
nice as spice
you will never have to worry again
are you objectifying me?
GOOD
because I'm objectifying you
and id rather not hear anymore about it
lets not argue with nature
its like a rock falling
arguing with gravity
all the way down.

https://medium.com/@4zebra2u/******-objectification-the-lie-that-keeps-on-lying-fb79223d016f
Amanda Stoddard Apr 2015
I broke again today.
The earth shattering at my feet
became a mountain beneath my toes
of all the things I should try to hold back.
Hold it back.
Deny yourself the freedom of expression
because it will linger upon your wrists.
Stop yourself here.
I try to stop myself in my tracks
but I end up getting stuck in the mud
and there's no one here to help me out
so I end up sinking again.
As the waste reaches my mouth
I am silenced.
The will I had to bring myself out of this mold
has vanished and I am a sinking ship once again.
No one ever tells you how to cope.
How to trace your fingers across scares you've made for yourself-
how to turn this madness into something so beautiful.
No one knows what it's like.

I was 17 when I discovered I had manic depression-
the words left my therapists lips like they were an execution notice.
"This isn't a diagnosis" she muttered
"This is who you are, who you've always been
it's not a death sentence".
But why did I feel as if I was being sent to death row-
to be hung by the noose I had made myself
out of tragedy and molestation and abuse.
There were no flowers at this burial.
Just a long awaited sigh of relief.
I always knew I wasn't like everyone else.
She drew me a picture of what it was like-
there were five stages of the imbalance living in my bones.
Major depression, dysthymia, normalcy, hypomania and mania-
she drew me a picture like she was trying to map me out
like she was drawing a Ned's declassified Bipolar Survival guide-
She explained it well.
How the days of normalcy tend to come and go again and again
but the mania and the major depression
pack their bags and stay awhile.
The major depression is like
a visit from a mentally abusive family member
that makes a point to tell you what the **** is wrong with you
when you already know, you tell yourself the same things everyday.
But the mania is like you're fun aunt that buys you beer
and tells you it's okay to **** whoever you want.
Get that piercing, dye your hair, who gives a ****?
The world is yours and the endorphin high you're on-
yeah that's your best ******* friend.
That's the aunt you wish you could be-
and sometimes they take you out on dinner dates-
they'll tell you how horrible you are and remind you
of all the things you have to be worried about.
They fill your head with nonsense and anxiety-
they convince you life would be better without you.
But then you remember what the mania feels like
when it's just the both of you bonding over ice cream
and spending too much money on thing you don't need-
you don't ever want her to leave..
"The mania is why most people don't get help" she said.

Mental illnesses are like actual illnesses-
they're a chemical imbalance in your brain
and you don't tell someone with diabetes
"Oh hey, just think that you're insulin is fine and it will be"
It doesn't ******* work like that.
See the Norepinephrine ran away when I was young
and the lack their of decided to hangout with serotonin.
They became best friends-
so I became the third wheel
and suddenly they both just stopped coming around.
I found a journal from when I was seven-
It said, "I don't want to be here anymore."
Most seven year old were taking care of furby's
or watching saturday morning cartoons-
But me? I wanted to end my life
like it was another ******* rerun
of the same episode you ******* hated
and all you want to do is turn it the *******
but there's really nothing else on TV
so you watch anyway.
Idly sitting there as you're hating every second-
But I'm still alive.
And these hands have dealt with more than just cuts
and pills bottles that became empty with mania that became worse-
I'm staring blankly at this page she drew for me.
Mapping out my mania like it's roller coaster tycoon
I think I'll call it Avalanche because ever since
I was labeled as having "Manic Depression",
I've been climbing my battles ever since-
even though some days, they try to fight back.  
There was a word to the way I was feeling
and a map to express it.
I felt like when I was young and I led Dora to the correct place-
all because of the map guiding her to her destination.
My therapist gave me the map-
she drew my way into understanding.
I haven't found my way home quite yet-
but at least I now know where I'm going.
this is about my manic depression, I got really inspired.
Chris Ott Dec 2011
you left sinkholes
in my head
large enough
to ensnare my
wildest, unfiltered
dreams. they're
now trapped in my
mind and lost in the
grey matter.

ashes to serotonin
norepinephrine to dust
ex nihilo nihil fit
Venny Mar 2016
Constantly searching for serotonin. Because norepinephrine won't let me breathe. Dopamine, you're my dream. Epinephrine you stagger me.
Megan Jan 2013
I walked into Walgreen’s that night
              absorbed in my own little world.

Soon after entering,
I made my way to the line.
My eyes
             d       a      n  c  e d        

to the crescent-moon shaped scar
    adorning the young clerk’s neck.

With the gentleman in front of me,
he spoke of
camouflage and machine guns.
                                                                            Earlier times when he
                                                                               could only see his
                                                                                  family through
                                                                                     the lens of
                                                                                            a
                                                                                      webcam.
When  he first learned what it took
                                       to be a man.

And when he learned what true loss
really felt like.

It’s my turn.
I step     f      o   r w ard
and stare directly into his eyes
and wonder

how he ended up here.


His face doesn’t give away much,
he’s painted on a cordial smile
and the air between us seeps
with the remnants
of small talk.

But I can’t help wondering.
I wonder, if he knows

he’s more than he’s been told.
       more than he’s settled for.
       more than the orders he was commanded to obey.
       more than the lines he was expected to cross.
       more than the monster he had to become.
                                                                                   To survive.

I can’t help but wonder

how he’s ended up here.

Overseas— he’s ranked
but now that he’s home
on friendly soil,                                    he’s thrown into department store
                                                                 positions and temporary jobs.
I can only hope he’s better off than some of his friends

tossed into
psychiatrists offices.

But I wonder,
I wonder what memories might decide to plague his dreams.
While he tries to figure out
which pill alleviates which painful recollection.
Which part of his past will come back to haunt him today
and which of his friends lives will flash before his eyes while he tries to sleep.

Norepinephrine firing through his brain
                                 like the gunshots he had to deliver.

The U.S government is so quick to draft,

but hasn’t learned how to welcome home.

They hide their veterans in the dark corners of psych wards,

allow them to get lost in the depths of their own minds,

while the PTSD
                                   eats away whatever is left.

These men fight for countries who don’t know what to do with them afterwards.
What they both need to learn:

There is life after war.
Qualia, if they exist, describe experience.

Perceptions are frames of consciousness
that define experience: would they be given a number
representing frames per second [FPS].

There must be something to perceive
for there to be experience, and the perceiver:
A machine/dreamer through which energy flows
for perception to occur; neural oscillation cycles
equating to perceptual frames of consciousness
where a frequency would equal a certain FPS.

A moment in a dream, a quale.
The realm of the Oneiroi beckons:

During REM sleep there is no experiential context,
Suppose a dream's content is be sourced from memory:
Thence memory morphs into dreaming. Perhaps the actions
of acetylcholine during sleep disrupt temporality, meanwhile
serotonin and norepinephrine play another role in dream activity;
Were dopamine ever-so minutely implicit in lucidity?

If a dream could be quantized could we identify a quale?
The goal, to prove that qualia exist. Perhaps this 'heavy realm'
could then be described using this qualitative formula, we strive
to produce a quantum of experience.

As analogue is to digital, so digital should be to quanta.
Ah, but who would ever listen
to my nonsense.

I'm just a dreamer
and such a chancer. (Aren't we all?)
Still working on a plausible explanation for SupCom.
They're such shiny chemicals:
Dopamine, Norepinephrine, Phenylethylamine.
Life shimmers,
and each day is painted with purpose
When dosed with such potency.

I would like to believe that love,
The long-lasting kind,
The one you're supposed to want,
The one that settles you,
Where you grow old and spend Wednesday evenings answering emails and rewatching some old baking show in ***** sweats
Is enough to keep life interesting.
But chemistry doesn't always work that way.

My path might dictate some other measure of wholeness,
And more than one type of love,
And more than a couched lookalike storybook ending.
My path may require
Risk, Adventure, Longing,
Questioning, Exploration, Pain,
Brilliant platonic wildfires,
Intellectual dalliances,
And unrequited amorosity.
In short, my path may require some trailblazing.

But this precious neural spark
In my body
That keeps me in love with love
Is mine to keep
For as long as it continues to shine.
7/26/18
Lia Apr 2015
oxytocin serotonin rhythm rhythmatic
a dopamine drip like a metronome tick
endorphins crash like waves

~ rest ~

epinephrine more like norepinephrine
neuropeptides simmer down &
monoamines die like flies
Arke Jun 2018
do you feel fight or flight
norepinephrine through your veins
my nails against your skin
body delicate and responsive
lips bruised and stung
as i lick, nibble, bite
i sense veins pulsing with blood
burning hot with adrenaline
and i want you so desperately
i long to consume your words
devour your lips
take you in entirely
ravaged
exhausted
i want to smell you
fear, arousal, excitement
your flesh against my tongue
the sweetest moment of all
is not the thrill of the chase
it's the moment predator
captures prey
Carabella Feb 2019
Interesting idea but probably not realistic
N
ot going to speak this out loud
Fact is, they will probably think I’m crazy
A
strange wanting to be nearer
Time to deep dive and reflect on this
U
nclear from the chemicals dopamine, seratonin, & norepinephrine
Annoying really, especially because it’s not convenient
T
ruly wanting to know what they feel
Ignorant to the signs
O
nly person that seems to “get me”
Nearly at my wits end but smitten
Tab Feb 2016
Love is just another word
4 letters
A chemical reaction
Dopamine, addictive as *******
Norepinephrine, adrenaline
Serotonin, can make one temporarily insane
Love is a science, not a poem
Its not passion its a reaction
This is an explanation
Not a love poem
I don't want to love you anymore
Jen Jul 2018
Sickened
In the bones,
Aching,
And sore.  

Crying
Uncontrollably,
Asking,
"What for?"

Laughing
Without
End,
At other times.

Fled
From the rush,
Attempting
To overcome it.

In the beginning,
Dopamine
And Oxytocin
Lined a glass ledge
Like Sugar and Salt.

Naturally produced,
Lost
Clear sight.

Shortly later,
Norepinephrine
Drenched
And dried
On the string
Of a kite,
Then took
Flight.
Darkly Jul 2016
Whether you're searching or not,
when you find, stumble upon, trip over that moment
That creaky stairstep,
that mug that fits your hand perfectly,
that note you can't help but play once you've found it,
that shooting star
Whatever creates that serotonin, that dopamine,
that norepinephrine

What do you do about it?

What eats up your sadness?

Other people's?
The biggest tiny parts are there.
George Cheese Jun 2014
Love is chemicals and impulses,
but despite this,
words cannot express
this girl I miss.

Love is an addiction,
and I need a fix,
a norepinephrine cocktail,
a dopamine kiss,
a feeling of bliss.
Norepinephrine is a chemical in your body which causes a similar effect to adrenaline, and dopamine "produces a feeling of bliss".
lucidwaking Jul 2021
We're chewing on pancakes,
And sipping cold coffee from wine glasses.
A record turns as we wistfully gaze outside,
Watching the weeds grow through cracks in the pavement.

A pill for you, a pill for me -
Without them we'd wear ourselves out.
They'll squeeze the norepinephrine and
Dopamine out of our neurons,
Just to keep us stable.
We toss them down the hatch,
Swallowing the chalky and bitter taste
Of uncertainty.

This is how we keep ourselves out of the hospital.
We listen to self indulgent music,
And keep our thoughts safe within these walls.
Dear friend, don't hang your head.
We'll be past this someday,
Maybe.

My psychiatrist promised I'd feel better,
So I'm going to try my best.
I'm sorry that your moods and mental state
Have been swinging like a brass pendulum,
To and fro;
Bleak lows and manic highs.
Let's take a stroll out by your old backyard pool,
With water black as ink.
Breathing in the crisp air
May help us clear our heads.

I'll always love you, you *****.
Call me and I'll come,
And we can wallow in our intrusive thoughts.
Grab my shoulder
So we can stand and fight the tides of life together.
Feedback and critiques welcomed!
Derek Tatum Jun 2017
Do peaceful moments just come of their own accord?
How much influence does stimuli have on contentment?
Cant be purely chemical.
Serotonin, cortisol, norepinephrine.
Like everything in life.....trying to find a balance with far to many variables.
An educated guess. A fun chemistry experiment, this life.
States of mind...
A mind ramble
Empire Nov 2019
There was a version of me
That wanted this
That wanted what I now have
Doing all the “functional” things
Looking alive
But she never could have anticipated this
I hate it
I don’t want it

ANY OF IT!!!

Take all this **** away from me
Just let me live
I know I’m betraying her
I’m betraying her dreams
I don’t want to give up on her
But she was misguided and confused
And now I’m suffering for it
I don’t want this
I don’t want this life
I don’t
I don’t
I don’t

TAKE IT AWAY FROM ME!!!

My heart screams
As the first tears in ages
Well up in my eyes
But they won’t fall
Because I’m not that sad
There’s too much serotonin in me
And dopamine
And norepinephrine
Because I’m ******* drugged
And I want to WEEP
But... I... I can’t...
I’m just unsteady
Unstable
I’m not okay
I’m not okay

I AM NOT OKAY
Canis Latrans Feb 2019
Norepinephrine. Serotonin. Dopamine.
Soloy Nov 2020
Love is an obsession
and all obsessions are unhealthy

To get rid of You
I must fill my mind with another


and the cycle continues again


unless.....



I am a thrill seeker
norepinephrine chaser

Your love pales in comparison

In the face of Death

— The End —