I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

I wish to age like a wrap-around porch
In a thunder storm,
While generations tell tales,
Sipping drinks.
A porch of blinking stars,
A shelter out of rain,
With ascending and descending friends.

I will age like a tree,
Grow stronger in the wind;
Give shade and shelter to all
Beneath my ring-aged limbs.

I wish to age as a river bends,
Contiguous with all shores;
Floating everyone I know
On eternal waters,
A current winding with no rest.

I will age like a star,
Burning bright, giving light,
Something to reach for.

I wish to age like a mountain,
With secret caves and riches.
And you can rock your soul
Around, over or through,
Solid, snow-capped summit,
Beckoning you.

I will age as the moon,
In stages, full and new;
Each night different,
Unnoticeable fading,
As all who age will do.

It was a cold night for a concert. There was frost on the windscreen as we got into the car for the short drive to this city church. We drove because we were going to be late, and it was cold, and would be likely to be colder still when the concert was over. I had wondered if part one would be enough. Could Bach and Rameau be enough? Might the musical appetite cope with Mozart and Beethoven too? Were we about to sit down to a large meal, possibly in the wrong order. Can the cheese course be a transcendental experience I wondered? Bach to begin certainly, a substantial starter with one of the mid period keyboard toccatas and two ‘distant’ preludes and fugues, but then a keyboard suite by Rameau?
 
When I listen to Beethoven though I want to hear a work on its own, unencumbered round about with other musics.  A recent experience of several hours driving to hear a single Beethoven symphony has remained close and vivid, and an experience that brought me close to tears. So I imagine that I might only hear Op.110 to make that opening sequence of chords so ominously special. The introduction seems to come from nowhere and does not connect with musical past, except perhaps the composer’s own past. It is as though the pianist puts on a pair of gloves imbued with the spirit of the composer, and these chords appear . . . and what is there that might possibly prepare the listener for the journey that pianist and listener embark upon?  Certainly not the soufflé of Mozart’s K.332.
 
The audience is hardly a smattering of coats, hats and grey hair. There is another piano recital in town tonight and this is but the artist’s preview of a forthcoming concert at a major venue. Our pianist is equipping herself for a prestigious engagement and sensibly recognizes the need to test out the way the programme flows in front of an audience, and in a provincial church where she is not entirely unknown. I admire this resolve and wonder a little at the long-term planning which makes this possible and viable.
 
Now a figure in black walks out from the shadows to stand by her piano. Coming from stage right she places left her hand firmly on the mirror-black case above the keyboard. She looks at her audience briefly, and makes a bow, almost a curtsey, an obeisance to her audience and possibly to those distant spirits who guard the music she is to play. We will not see her face again until the next time she will stand at the piano to acknowledge our applause after the Bach she is about to play. Her slightly more than shoulder-length hair is cut to flow forward as she holds herself to play; her face is often hidden from us, her expression curiously blank. Perhaps she has prepared herself to enter a deep state of concentration that admits no recognition of those sitting just in front of her. Her dress is long and black with a few sparking threads to catch the careful lighting. Without these occasional glimmers her ****** movement would be unnoticeable. As it is the way the light is caught is subtle and quietly playful, though not enough to distract, only remind us that though in black she is wearing the kind of starry sky such as you might perceive in crepuscular time.
 
Thus, we already sense so much before she has played a note there is a firm slightly dogged confidence and reverence here in her approach to instrument and audience. And in the opening bars of the Bach toccata that is manifest; and not just a confidence born out of some strategy against nervousness, but a ritual of welcoming to this music that now spills out into the partially darkened church. The sonorousness and balance of the piano’s tone surprises. It is not a fine piano, but it has qualities that she seems to understand. There is a degree of attentive listening to herself that enables her to control dynamics and act resolutely on the structure of the music. When the slow section of this four-part toccata appears there is a studied gentleness and restraint that belies any ****** led gesture or manner. Her stance and deliberation at the keyboard remain determined and in control, unaltered by the music’s message. She does not pull her body backwards as seems the custom with so many who feel they have to show us they are stroking and coaxing such gentleness and restraint out of the keyboard.
 
As the final fugato of the toccata flows at almost twice the speed I’ve ever heard it, my concentration begins to disengage. It is too fast for me to follow the voices, I miss the entries, and the smudged resonance of the texture hides those details I have grown over so many years to know and love. This is Glen Gould on speed, not the toccata that resides in my musical memory. I am aware of missing so much and my attention floats away into the sound of it all. It seems to be all sound and not the play of music.
 
In this stage of disengagement I sense the tense quality of her right leg pedalling with the tip of a reddish shoe just visible, deft, tiny flicks of movement. She turns her face away from the keyboard frequently, looking away from the keyboard through the choir to the high altar; and for a moment we see her upturned face, a blank face, possibly with little or no make up, no jewellery. A plain young woman, mid to late thirties perhaps, and not a face marked by children or a busy teaching life, but a face focused on knowing this music to a point at which there is almost a detachment, where it becomes independent of her control, flowing momentarily beyond herself.
 
Then she reins the toccata in, reoccupies it; she is seeking closure for herself and for her audience whose attention for a short while has been, as the Quakers say, gathered. Gathered into a degree of silence, when breathing and the body’s sense and presence of itself disappear, momentarily, and musical listening moves from a clock time to a virtual time. There is a slowing down, an opening out, even though in reality’s metronomic time-field there is none.
 
There is a hesitation. With more Bach to follow, should we applaud? With relief after holding the flight of time’s arrow in our consciousness, just for those concluding minutes and seconds we acknowledge and applaud - the beginning of the concert.

I love it when I notice others
using the same vocabulary
or phrases as me

And while my mouth may remain
a straight line
in efforts to portray indifference,
my heart is smiling
from beat to beat
because it means that
you held me so close
that a bit of who I am
rubbed off onto you

It makes me feel as though
I’ll always be a little part of you,
disguised by letters,
unnoticeable to anyone else

But I see it (I see bits of me in you)

I’m still with you,
and I wonder if you can see it, too.

Lost by  our own illusions
Only we know true ambitions
Never part of the large crowd
Everyone teases us and laugh
Really we are just unnoticeable

If I get lost, promise you'd leave me be
Let me walk alone in my circles
I'll find my way back...almost instinctively
Through looping thoughts and scribbles

If I should trip, promise you'd let me fall
Scrape my knee and scream a voiceless scream
Weight of the universe may seem crushing to shoulders so small
I'll walk it off and regain newfound steam

If I show signs of buckling, promise you'd let me collapse into nothing
Let me fold into myself...into an unnoticeable speck
There is solace in this space when the walls are caving
Soon I would reinvent and renew from that wreck

If I suffer a cut, promise you'd just let me bleed
Let the black of my soul gush out
Within it I would find the seed
To which all of my rantings are about

If I should begin to write, promise you'd read my scrawls
Take them as they are and not to heart
Just thoughts versus words that mean much or nothing at all
They'd stitch me anew when I start to break apart

If I keep losing myself, promise that you'd let me be
The circles I tread are very much predictable
They'd always lead me around... Don't treat me differently
Just stay where you are... I'll come back round, fresh and able...

To some she is a shining light
A flash of hope amongst the dark
An optimistic helping hand
To pull you from the dark
And cheer your sorrow

To some she is a black hole
Pulling the world down with sadness
Reliving the past that broke her
And stabbing others with the shards

To some she is simple words
plastered on a white canvas painting a picture.
never more
but never less

To most she is unnoticeable
A tiny footnote scribbled in the corner of a forgotten notebook
A wall flower whose thorns push away all but those with the key to her locked heart.

When you ask me what she is
The answer is impossible
Because I don't know

But I can tell you what she's not

She is not a beautiful face, to stop you in a crowd

She is not a chatting girl to talk you into a date

She is not a innocent flower
Welcoming with open arms

She is not a genius to create the next invention

She is not a musician, an author, a designer, a star, a doctor, or a hero

She is not a loving companion for you to hold, and remember your every need

She is not a great friend, always there in a flash.

She is not a friendly person, starting up the conversation

She is not a good cook, making meals that are edible

She is not an unscarred girl, unscathed by the past

She is not a beautiful figure
That draws your eyes

She is not hilariously funny
Ready for stand up comedy

She is not someone to remember though she will remember you

However she is not fazed by judges
Changing ways to suit them

She is not perfect

She is not stopped by her imperfections, only pressed farther to become something more.

And though I can not say who she is or what she will be. Here's what I can say

To me she will always be the girl staring back in the mirror.

When love hits two people
It's far beyond their capacity
It's not a choice.
Like God, bored in his kingdom,
Ordered the angels
To stitch them together
As one piece of fabric
Through thick and thin.

Then the Devil, jealous of such union,
Does his best to set them apart again.
He tries loosening the threads,
Uses scissors to rip them.
He even makes little unnoticeable holes
Just to damage the cloth.

But they must be smart
They must see through his villain attempts
At spoiling the embroidery of love
God sewed on the cloth of their heart.
They must resist.

Sometimes they do
Sometimes they don't.


F.Z.**N