I've been acquainted with the following
psychoactives compounds:

Depressants & Dissociatives;
Ethanol / EtOH / alcohol, drink, *****
γ-Hydroxybutyric acid / GHB / G, fantasy
β-Phenyl-γ-aminobutyric acid / PhGABA / Phenibut
Dextromethorphan / DXM / Benylin, Robitussin
Morphine / Papaver somniferum / *****
3-Methylmorphine / Codeine
Dihydrocodeine / DHC
Buprenorphine / Subutex, Suboxone
N-Allylnoroxymorphone / Naloxone / Suboxone, Narcan
Tramadol / Ultram
O-Desmethyltramadol/ O-DSMT / Omnitram
Thiopental / Sodium Pentothal
Diazepam / ******
2'-Chlorodiazepam / Ro5-3448 / Diclazepam
4'-Chlorodiazepam / Ro5-4864
Chlordiazepoxide / Librium
Gidazepam, hidazepam
Desalkylgidazepam / Bromonordiazepam
N-Desalkylfluarazepam / Norfluarazepam
Flubromazepam
Alprazolam / Xanax
Bromazolam / XLI-268
Clonazolam, Clonitrazolam / Clam
Etizolam / Etilaam, Etizest
Flualprazolam
Flubromazolam
Zopiclone / Zimovane
Pagoclone
Promethazine / Phenergan
Diphenhydramine / DPH / Benadryl, Nytol
Chlorphenamine, chlorpheniramine / CPM / Piriton
Cetirizine / Zyrtec
Amitriptyline / Elavil
Tianeptine / Coaxil, Stablon
Mirtazapine / Remeron
Quetiapine / Seroquel
Nitrous Oxide / N2O / laughing gas
Amyl Nitrite / Poppers
Ketamine [racemic] / K, Kitty
Esketamine [S-isomer] / Special K
Deschloroketamine / 2'-Oxo-PCM / DCK
N-ethyldeschloroketamine / 2'-Oxo-PCE / O-PCE / Eticyclidone
Deoxymethoxetamine / 3-Me-2′-Oxo-PCE / DMXE
Methoxetamine / 3-MeO-2'-Oxo-PCE / MXE / Mexxy
Hydroxetamine / 3-**-2'-Oxo-PCE / HXE / Hexxy
Methoxpropamine / 2-Oxo-3'-MeO-PCPr / MXPr
Methoxisopropamine / 2-Oxo-3'-MeO-PCiPr / MXiPr
3-Hydroxyphencyclidine / 3-**-***
3-Methoxyphencyclidine / 3-MeO-***
3-Methoxyeticyclidine / 3-MeO-PCE
3-Methyleticyclidine / 3-Me-PCE

Stimulants & Enhancers;
1,3,7-Trimethylxanthine / Caffeine / Coffea, Camellia sinensis / Coffee, Tea
3,7-dimethylxanthine / Theobromine / [constituent of] Chocolate
N-Ethyl-L-glutamine / L-Theanine / [constituent of] Green Tea
Nicotine / Nicotiana / Tobacco, cigarettes, smokes
Ephedrine / Ephedra
Pseudoephedrine / Ephedra, Sudafed
Adrenaline, Epinephrine
Choline bitartrate
L-alpha glycerylphosphorylcholine / Alpha-GPC, Choline alfoscerate
Cytidine 5'-diphosphocholine / CDP-choline, Citicoline
N-Acetylcysteine / NAC
2-Dimethylaminoethyl (4-chlorophenoxy)acetate / Meclofenoxate
N-Phenylacetyl-L-prolylglycine ethyl ester / Omberacetam / Noopept
Coluracetam / BCI-540
4-Phenylpiracetam
Propranolol
(±)-2-Benzhydrylsulfinyleth­anehydroxamic acid / Adrafinil
(±)-2-[(Diphenylmethyl)sulfinyl]acetamide / Modafinil
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide / Armodafinil
α-Methylphenethylamine / Amphetamine, αMP / Speed
N-Methylamphetamine / Methamphetamine / ****
Lisdexamfetamine / Vyvanse, Tyvense, Elvanse
2-Fluoromethamphetamine / 2-FMA
3-Fluoroamphetamine / 3-FA /  PAL-353
4-Fluoroamphetamine / 4-FA, 4-FMP /  PAL-303 / Flux
4-Methoxyamphetamine / PMA, 4-MA / Death
5-Methoxy-2-aminoindane / MEAI, 5-MeO-AI / Chaperone, Pace
Methythiolpropamine / MPA / Blow
3-Fluorophenmetrazine / 3-FPM / PAL-593
Methylphenidate / MPH / Ritalin, Concerta
4-Fluoromethylphenidate / 4F-MPH
4-Fluoroethylphenidate / 4F-EPH
3-Methylmethcathinone / 3-MMC / Metaphedrone
3-Methylethcathinone / 3-MEC
4-Methylmethcathinone / 4-MMC / Mephedrone
4-Methylethcathinone / 4-MEC
3-Chloro-N-tert-butyl-cathinone / Bupropion / Wellbutrin, Zyban
4-Chloromethcathinone / 4-CMC / Clephedrone
4-Fluoromethcathinone / 4-FMC / Flephedrone
4-Fluoro-α-methylaminovalerophenone / 4-Fluoropentedrone / 4-FPD
α-Ethylaminocaprophenone / N-Ethylhexedrone / NEH / Hexen
alpha-Pyrrolidinohexiophenone / α-PHP / PV-7
alpha-Pyrrolidinoisohexaphenone / α-PiHP, α-PHiP
3,4-Methylenedioxy-α-pyrrolidinohexiophenone / MDPHP
3,4-Methyl​enedioxy​pentedrone / βk-MBDP / Pentylone
3,4-Methylenedioxymethcathinone / βk-MDMA / MDMC / Methylone
3,4-Methylenedioxymethamphetamine / MDMA / ecstasy
5-(2-methylaminopropyl)benzofuran / 5-MAPB
6-(2-Aminopropyl)benzofuran / 6-APB / Benzofury
6-(2-Aminopropyl)-2,3-dihydrobenzofuran / 6-APDB / 4-desoxy-MDA
Mesembrine / Sceletium tortuosum, Kanna
Harmine / Peganum harmala / Syrian Rue
3,4,8-Trimethoxyphenanthrene-2,5-diol / Dendrobium nobile
NSI-189
4-chloro-N-(2-morpholin-4-ylethyl)benzamide / Moclobemide
Escitalopram / Cipralex, Lexapro
Fluoxetine / Prozac
Sertraline / Zoloft
Venlafaxine / Effexor
5-Hydroxytryptophan / 5-HTP / Oxitryptan

Hallucinogens & Psychedelics;
Cannabidiol / CBD / Cannabis
Cannabigerol / CBG / Cannabis
Δ9-Tetrahydrocannabinol / THC / Cannabis, Marijuana
Hexahydrocannabinol / HHC
AM-2201 / Synth-'noids, Spice
NM-2201 / CBL-2201
5C-AB-PINICA
Salvinorin A  / Salvia Divinorum / Diviner's Sage
d-Lysergic acid amide / d-Lysergamide / LSA / Ergine
Lysergic acid diethylamide / Lysergide / LSD, LAD / Acid, Lucy
Lysergic acid 2,4-dimethylazetidide / LSZ / Diazedine, Lambda, λ
1-Acetyl-lysergic acid diethylamide / 1A-LSD / ALD-52
1-Propionyl-lysergic acid diethylamide / 1P-LSD
1-Cyclopropionyl-N-Methyl-N-isopropyllysergamide / 1cP-MiPLA
6-Allyl-6-nor-lysergic acid diethylamide / AL-LAD / Aladdin
2,5-Dimethoxy-4-methylamphetamine / DOM / Dominic
2,5-Dimethoxy-4-bromoamphetamine / DOB / Aphrodite
2,5-Dimethoxy-4-chloroamphetamine / DOC / Doctor
2,5-Dimethoxy-4-methylthioamphetamine / DOT / Aleph
2,5-Dimethoxy-4-methyl-α-ethylphenethylamine / 4C-D / Ariadne
2,5-Dimethoxy-4-methylphenethylamine / 2C-D, 2C-M / Matrix
2,5-Dimethoxy-4-ethylphenethylamine / 2C-E / Eternity
2,5-Dimethoxy-4-bromophenethylamine / 2C-B / Nexus
2,5-Dimethoxy-4-chlorophenethylamine / 2C-C / Callisto
2,5-Dimethoxy-4-iodophenethylamine / 2C-I / Infinity
2,5-Dimethoxy-4-methylthiophenethylamine / 2C-T / Tesseract
2,5-Dimethoxy-4-ethylthiophenethylamine / 2C-T-2 / Rosy
2,5-Dimethoxy-4-fluoroethylthiophenethylamine / 2C-T-21 / Aurora
2,5-Dimethoxy-4-bromo-β-keto-phenethylamine / βk-2C-B
2,5-Dimethoxy-4-bromo-β-hydroxy-phenethylamine / βOH-2C-B / BOHB
2,3,6,7-Benzo-dihydro-difuran-8-bromo-ethylamine / 2C-B-FLY
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-bromophenethylamine / 25B
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-chlorophenethylamine / 25C
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-iodophenethylamine / 25I
2,5-Dimethoxy-N-(2-hydroxybenzyl)-4-ethylphenethylamine / 25E-NBOH
3,4-Methylenedioxyamphetamine / MDA / Sass, Sally
3,4,5-Trimethoxyphenethylamine / Mescaline / M
3,5-Dimethoxy-4-ethoxyphenethylamine / Escaline
3,5-Dimethoxy-4-methallyloxyphenethylamine / Methallylescaline / MAL
α-Methyltryptamine / αMT / Indopan
N,N-dimethyltryptamine / DMT / The Spirit
N,N-dipropyltryptamine / DPT / The Light
N,N-Diisopropyltryptamine / DiPT / The Sound
N-Methyl-N-ethyltryptamine / MET / The Colour
N-Methyl-N-propyltryptamine / MPT
N-Ethyl-N-propyltryptamine / EPT
N-Methyl-N-isopropyltryptamine / MiPT / The Touch
4-Hydroxy-dimethyltryptamine / 4-**-DMT / Psilocybe / Psilocin
4-Phosphoryloxy-N,N-dimethyltryptamine / 4-PO-DMT / Psilocybin
4-Acetoxy-dimethyltryptamine / 4-AcO-DMT / Psilacetin
4-Hydroxy-N-methyl-N-ethyltryptamine / 4-**-MET / Metocin
4-Acetoxy-N-methyl-N-ethyltryptamine / 4-AcO-MET / Metacetin
4-Acetyloxy-N,N-dipropyltryptamine / 4-AcO-DPT / Pracetin
4-Acetoxy-N-methyl-N-cyclopropyltryptmine / 4-AcO-McPT
4-Acetoxy-N-methyl-N-isopropyltryptamine / 4-AcO-MiPT / Mipracetin
4-Hydroxy-N-methyl-N-isopropyltryptamine / 4-**-MiPT / Miprocin
5-Methoxy-N,N-dimethyltryptamine / 5-MeO-DMT / The God, The Power
5-Methoxy-N-methethyltryptamine / 5-MeO-MET / The Vision
5-Methoxy-N,N-diallyltryptamine / 5-MeO-DALT / Foxtrot
5-Methoxy-N-diisopropyltryptamine / 5-MeO-DiPT / Foxy
5-Methoxy-N-methyl-N-isopropyltryptamine / 5-MeO-MiPT / Moxy

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

I have two facts for you that exist in my mind -
1. I am normal
2. I do not 'feel' normal
I have never considered myself to be normal.
I knew i wasn't normal when at the age of eight after my Dad left my school hired a counsellor just for me,
and i wasn't normal how after then i was the only pupil to be from a single parent family.
I wasn't normal when just after this abandonment my body entered early puberty,
and so feeling weird didn't stay a feeling, it became a reality.
Picked on for things out of my control, i felt like a freak.
Even at the age of eight, every aspect of my identity was up for scrutiny.
I knew i wasn't normal when in secondary school i would purposely get detentions
to spend time with teachers, because the the turmoil of the school yard was a teenage no man's land.
The company of those my own age is something i will never understand.
I knew i wasn't normal when i would hesistate in conversation when someone asked me who i fancied in my class.
The name of a random boy rolled from my tongue in an attempt to not blow my cover.
I knew i wasn't normal when my tweets coming out as bi were passed around like breaking news.
When i tried to defend myself in the interrogations, teachers would sternly say to me -
'That's not appropriate to be talking about in school' like my sexuality was a hushed secret, even though the straight girls were never silenced.
I knew i wasn't normal when i had to say i was bi, when in fact this was a lie. A lie to help me pass, pass and hold on to some straight privilege.
At the age of sixteen i questionned my worth and value as a person, trying to blame myself for the treatment i was subjected to.
I knew i wasn't normal when i decided to place my emotional pain onto a physical space, then patching up the damage as a form of ironic self-care.
I left school for a college, desperately seeking freedom from the constraints of a Catholic school.
I never felt comfortable in sixth form, being there my mind felt like a spinning waltzer i was strapped to for two years.
At seventeen i knew i wasn't normal when i was prescribed the maximum dose of sertraline, then mirtazapine, venlafaxine, fluoxetine.
By this point in my life i was on a tally of maybe six counsellors and two CBT therapists.
I knew i wasn't normal when i started to blame myself for the therapy not being successful. Maybe i was just meant to be depressed.
Changing my thinking styles, emotional regulation, journalling my feelings and triggers, i knew exactly what i had to do.
I knew i wasn't normal when i clung onto certin things as comfort, like my adoration for florence and the machine.
I started to experiment, toying between wanting to fit in and wanting to be myself, painting bright eyeshadow on my lids as a vibrant mask to carry me through.
I knew i wasn't normal when i reached out to the local crisis team experiencing auditory hallicinations, hearing sounds only meant for my ears.
My emotional states are a product of my trauma, which is difficult to navigate as the world's greatest performer.
Maybe i was meant to face this internal torment, or until now i hadn't considered i could be neurodivergent.

It's not the kind of sadness which makes you want to cry all the time,
But the kind of sadness that overwhelms your senses so much,
You began to question your sanity
You lost touch with all your emotions.

Venlafaxine in the day
A little white pill,
Promising you no more break downs.

Sertraline in the evening
Two little blue pills,
Selling you dopamine and fake smiles.

Quetiapine in the night
Three little pink pills,
Swearing that you'll be in control.

Those lies they feed you
False hope sold in crazy little pills,
I still clutch the bottle of gas
Dreaming of normalcy,
Cradling a razor blade on broken skin
I smile like a fool.

Take these, they say;
They will help, they say.

How ‘bout some venlafaxine?
That will stop you wanting to die.

Bit anxious?
Some lorazepam will fix that!

Oh, how’s your sleeping?
Temazepam, zopiclone!
That’ll do the trick.

Your mood is unstable?
We have something to cure that!
We’ll add on some lithium and quetiapine,
How does that sound?

You’ll be all better in no time.

You take the pills,
Two in the morning (with a large glass of water)
During the day (as needed)
Three more in the evening (after food)
And three at night (an hour before bed)

Am I all better yet?

Well, I guess I don’t feel anxious..
And my mood isn’t all over the place…

In fact; I don’t have a mood at all.

Nothing.

Zombiefied.