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I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.
Shofi Ahmed May 2021
Zindagi ki piyala itna borha nahi hai
ki uski andor me lehron ki mujhme
nodia beh sakta hai.
Likhen uski andorme ek bindu
pani bi nahi itna chota
ki isme sagor bon nahi sakta.

Koi yaro achanok milta hai to bolta
kitna chota hai ye donia
Ye mitti andorme bi kya borha?
Khodo to isme kobor bonta hai
Liken agor Mawla chahe to ye
mitti se bi Adam bon sakta hai.

Somundor to somundar
shabnam (dew) bi Subhan Allah!
Aaj kaha aj reh ta hai kal ** jata
Kal ko kisi ko kiya pa tha
Thalu aftab (sunrise) ki canvusme
Ankhi dal kor job sham dol jata hai
Kisi Ko zulf ke saye me bemalum
Kitne ankhi khu ja ta hai
Kis andaar goliche chad aa ta hai
Kiso ki kiya pa tha hai
Liken mera bhi kitna khush naseeb hai
Khali hate aakor bi itni kimti herat angaiz
(amazing) majlish me ek hishya bhi mila.
Mawla karega keyse Aap ka shukrana
Alhamdulillah kiyanat ki Rab taarif Aap ka, Aap ka!
A thought on my birthday perhaps applies to everyone.
pigeungdom er sprukne læber, fugtige øjne, blege hænder, rystende ben, grønne sind, papmache-hjerter, neglebidning, rifter på håndledene, blå mærker på halsen, tabt alkohol og knækkede cigaretter i tasken, makeuprester, ***** mod rug tunge, maveknurren, ar på hoften, varme radiatorer, gratis drinks, tunge øjenlåg, kortvarig lykke, falske grin, personlighedsspaltning, pengestress, ligegyldige kys, søgen efter tryghed, gåsehud, spildt kaffe, brandsår, våde cigaretter, dybe vandpytter, natbusser, angstdæmpende medicin, fællesdepressioner, et kor af gråd, irrelevante samtaler og et sløret omrids af et ansigt, der smadrer din nattesøvn, og gør det svært at stå op
wyle tan Sep 2016
When we go alone on a one-way journey
Leaving behind family, home, friends
We weep the loss

Loneliness and sadness fill our hearts
With misty eyes we wave goodbye

A struggle begins within
To leave or to stay
Leaving this weariness
Staying with familiar memories

Only comfort we know
A new tomorrow
Only to meet again
Joanna Garrido Jan 2019
Bewitch me, Ayesha, in volcanic realms
to bathe in the flames of your pillar of light
Sorceress of beauty, your power overwhelms
your enchanted incarnate, returned from the night
Ageless and timeless, in Kor once revered
Lost in your eyes, in your spellbinding gaze
Two millennia existed, now cruel and feared
by the people you’ve ruled in formidable ways
Step into the blue flames, to melt and to burn?
To give reassurance you step in the blue
caressing your body, erotically turn
Eternal life beckons in harmony with you
We bathe in the light so forever exist
Ayesha, Kallikrates ever entwined
Then time to step out, but a terrible twist
Ayesha you whither likes grapes on a vine
Your body is shrivelling, you’re turning to dust
Before me my lover gone back to the earth
Now I reincarnate forever to lust
for you to come back to me, for your rebirth
I pine for you, grieve for you, calling your name
What you failed to know of the blue fire’s curse
is that once you may enter the magical flame
but the second time all of its powers reverse.

30.12.18 JG
In dedication to Rider Haggard’s She. The Hammer film was very watchable too
certifiednutcase Mar 2014
Unknown and foreign to light
Feeling the emptiness hence cry.
1 and 11 months dad left,
Guileless kid that I was
Didn't care.

Grandma's place during the weekdays
With Kor as my playmate.
You'd think we were inseparable
But we grew up.

Doted on due to pity
Doesn't quite last.
When you're a annoying seven year old,
Single parented or not, who cares?

No one to turn to,
Seeing mum only morning and night.
Keeping it all to myself,
That's how I grew up.  

Nine year old was hell
Crying to sleep silently,
Worrying about how to act,
A smile to cover it up.  
No one cared enough to ask.

Time flew and at 15
We finally moved "home".
Little space I once possessed
Grew to naught.

The first slash, the first purge.
No one knows.
The first attempt, the consequent ones
No one cares.

Nothing was ever easy.
At 16 and 4 months I look back
Thinking how the hell I survived it all
Thinking how the hell am I going to move on.
Muzaffer Apr 2019
meltemin
yüzüme savurduğu çiçeği kokluyor
büyülü straplezi gecenin

fısıldıyor
cesur ve utanmaz..

sayalım
göğün kızlarını yine

sen sağdan, ben soldan
kirli sözler söyle bana
duralım 70’e 1 kala, ama
ağzın doluyken konuşma

ki bilirim
yakar nefesin
alazı kor dudaktan
tutulur grizuya
kasılırım yeni baştan

ve
bilirim
orda
gündoğumunda

kenarında yatağın
boşalırız aynı anda
deliksiz bir uykuya...
Norbert Tasev Feb 2022
A hundred years from now, a party girl, a cosmetic, plasticised goddess, will be so at home that she will be despised by the average man, as one who fears for his petty career and trembles! Honour deliberately digs a pit in the bottom of the pit of calculating games, and no one cares about the chattering mouth-carat of the puppets in the tabloid media!

The new-avant-garde prose line of poems is shouted down, saying: one-night stands have more east! Morals and humanity long since shed, mothers of children can't know what an uncertain livelihood and a messy tomorrow might bring!


The trembling, weeping cries of the little angels shiver like painful vapours in the abandoned alleyways of the streets! - What this present ******* Kor is extracting from itself, and creating, its pathetic beneficiaries are also, like molehills, hiding in underground, apocalyptic worlds, chewing on the hard-to-get, gnawing colonies!

A greedy food-chain insidiously lurks in the tunnels of each one's secret instincts; the strong devour the weak, the weak the weakest, and while the Golgotha-stricken vulnerable clamour for more reprieves from the company of lords and petty kings, their pathetic shipwrecked lives are consciously fearful - no-man's-land, fly-**** infects their chances of survival too!

— The End —