I found my soul at 300 baud
in a world the world would one day come to adore
before there were webs
we were the spiders
before there were laws
nothing could be denied to us
we were wardialling before cybercrime
we were a virus before virii became a fake news byline
but if busted I'll deny I ever tried to
break a trunk through MCI jamaica
sat on ******* station for days
raking in creds like a madmuhfuhn rap master
with nothing greater than a pair of headphones
and a cheap cassette tape deck to take me there
kids today dont respect what they play with
back in the day we had to be outlaws
to connect to todays day to day bandwidth

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

In the depths of my basement
Hidden behind the christmas decorations
And under the family albums
Lies a box waiting to be discovered
It holds a legend from a bygone era
The atari 2600
It may be the grandfather of gaming
But it still plays like it's 1977
It's been going strong for forty years
But my laptop called it quits after five
You have to start with the classics
Like Pacman pitfall and pong
Galaga asteroids and dig dug
All of them in glorious 8 bits
A throwback to simpler times
When there were no updates to download
Nothing to install to the hard drive
12 year Olds didn't mock you online
It was just you and a joystick

From 3 p.m. Monday to 3 p.m. Tuesday
<h2>Police calls
<h3>LA CROSSE
3:39 p.m., Hit-and-run, 4400 block of Hwy. 16
4:11 p.m., Theft, 3700 block of Hwy. 16
4:41 p.m., Hit-and-run, 1100 block of State St.
5:37 p.m., Domestic disturbance, 1000 block of Charles St.
5:42 p.m., Theft, 2100 block of Liberty St.
5:59 p.m., Fight, Fourth and King sts.
8:08 p.m., Theft, 2400 block of Rose St.
8:08 p.m., Domestic disturbance, 400 block of Sixth St.
8:37 p.m., Domestic disturbance, 1000 block of Fifth Ave. S.
10:14 p.m., Domestic disturbance, 1600 block of Adams St.
11:32 p.m., Domestic disturbance, 1400 block of Avon St.
2:38 a.m., Domestic disturbance, 900 block of 16th St.
8:25 a.m., Theft, 3300 block of Rosehill Place
8:25 a.m., Theft, 1000 block of Ninth St.
8:26 a.m., Theft, 500 block of Main St.
8:26 a.m., Theft, 1400 block of Johnson St.
8:34 a.m., Theft, 400 block of Seventh St.
9:24 a.m., Entry to dwelling, 1600 block of Caledonia St.
9:51 a.m., Theft, 400 block of Liberty St.
11:01 a.m., Fraud, first block of Copeland Ave.
12:16 p.m., Entry to dwelling, 1000 block of State St.          
<h3>ONALASKA
6:06 p.m., Animal bite, 2600 block of Midwest Drive
<h3>WEST SALEM
7:40 a.m., Vandalism, 3400 block of Hwy. 16
12:13 p.m., Theft, 900 block of Hwy. 16
<h3>BANGOR
9:24 a.m., Theft, 1800 block of Commercial St.
<h2>Fire Calls
<h3>LA CROSSE
3:01 p.m., Accident with injury, Fourth and Mississippi sts.
4:11 p.m., Accident with injury, 4500 block of Hwy. 33
4:26 p.m., Accident with injury, Hwy. 16 and 157
5:45 p.m., First responders, 700 block of Oakland St.
6:18 p.m., First responders, 1800 block of Pine St.
6:40 p.m., Accident with injury, Main and Fourth sts.
9:27 p.m., Natural gas odor, 700 block of Ninth St. N.
10:16 p.m., First responders, 1600 block of Adams St.
10:20 p.m., First responders, 900 block of Vine St.
1:54 a.m., First responders, 4100 block of Velmar Court
8:34 a.m., First responders, 400 block of Seventh St.
9:01 a.m., First responders, 400 block of Seventh St.
10:41 a.m., Accident with injury, Ninth and Vine sts.
10:45 a.m., Carbon monoxide report, 1500 block of Main St.
10:46 a.m., First responders, 400 block of Gillette St.
11:04 a.m., Accident with injury, 1300 block of Rose St.
11:10 a.m., First responders, 1500 block of Rose St.
11:14 a.m., First responders, Fourth and King sts.
11:31 a.m., Accident with injury, 16th and Main sts.
12:05 p.m., Accident with injury, 200 block of Pearl St.
1:12 p.m., Accident with injury, Hood and Miller sts.
2:26 p.m., Accident with injury, 21st St. and Park Ave.
<h3>ONALASKA
3:30 p.m., First responders, 1000 block of Westview Circle
5:09 p.m., Accident with injury, 1200 block of Hwy PH
8:02 p.m., First responders, 300 block of 12th Ave.
8:43 p.m., First responders, 300 block of 12th Ave.
8:50 p.m., First responders, 200 block of Oak Forest Drive
9:47 p.m., First responders, 200 block of Carol Lane
6:12 a.m., First responders, 1000 block of Frances Court
10:41 a.m., First responders, 7200 Northshore Lane
11:27 a.m., Accident with injury, Grant St. and Hwy. SN
11:35 a.m., Accident with injury, Commerce and Abbey roads
11:53 a.m., Accident with injury, 300 block of 11th Ave.
12:14 p.m., First responders, 5500 block of Commerce Road
1:08 p.m., First responders, 400 block of Kimberly St.
1:42 p.m., Accident with injury, 600 block of Second Ave.
<h3>HOLMEN
9:59 p.m., First responders, 1500 block of Viking Ave.
10:50 a.m., Accident with injury, Sand Lake Road and Laurel Place
1:32 p.m., Accident with injury, 1400 block of Main St.
<h3>WEST SALEM
8:53 a.m., First responders, 500 block of Elm St.
11:09 a.m., First responders, 300 block of Franklin St.
<h3>MELROSE
1:21 p.m., First responders, 9700 block of Hwy. 108

I found god
on my front porch
and we drank vermouth
from 12:00 to 12:00.
He spoke of how
he's trying to quit
cigarettes and women.
We raised our glasses
to that one.
I spoke to him
about how much I enjoy
asking people
how they really feel.
I told him how the earth
is rotating very quickly lately,
and that the centrifugal force
is improving the circulation in
my fingertips,
and how I'm starting to be able
to feel again.
He spoke of how
he had quit his job
to pursue a career
as a ceramic artist,
though he also claimed
he had always been one.
It turns out that god
is a neighbor of sin,
cut wide open
by the hope that lives
in the hearts of people
younger than us.
I told him
that I understand.
He filled my glass up again,
and then his own.
We did not speak of women.
He lit us a cigarette
and we shared it.

I feel like god
has been misunderstood
all this time.

I think he feels
the same way.

three times
one: i sit here on my friend's kitchen floor with a bottle of pills and a throbbing headache 'just take a few they're 200mg each you'll be fine'
i smile and nod, she walks out
i begin counting '200, 400, 600, 800, 1000...' all the way up to 2600
"what will 2600mg of ibuprofen do to me" i wonder
and i down the pills
hours later im fine
nothing
im not hurting
just numb once again as always
and i eat
then like usual, go puke it


~the summer before 7th grade~
just a little more dead inside than before