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I thought it right to assess some antidepressants, which philosophers should be more inclined to call mood enhancers.
(This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.)

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect. I therefore approached them with the notion that a limited dosage might point to their character which would further manifest in the long-term. (Side-effect were this unlikely to be fully manifest.) These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin reuptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavour of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, intresting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I correctly surmised it has a high affinity for 5-HT2C but was also surprised to find it is is quite adrenergic.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically intresting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energising yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires utmost caution.

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan), indications of a mild serotonin syndrome later became apparent. Symptoms included feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.
Sebastian Macias May 2016
His eyes were now open

Same familiar ache in his stomach,

Slight headache, he still had warm skin

She would sleep closer to him because of that

Very aware of where he was, what he was doing

He rose out of bed with purpose, took a breath

In front of him was a skyline view of the city

Clouds sat over the tall buildings, the sky was grey

There was a faint  noise coming

From the streets below him -

He was up before the sun and there was no

Light to shine against his dark wooden floors

Taking another deep breath

He gently let his head descend

Remembering when he was passing a church school

On a similar gloomy day when he was a young boy

The man slowly walked away from his bed

And into the living space of his home

Marvelous kitchen, with perfect home décor

Scattered across the entire place with elegance

He loved the smell of coffee in the early morning

Standing there with great physique

He looked towards his two friends -

Who had fallen asleep on the sofa comfortably

Family to him in his eyes, a beautiful bond between them all

One looked up at him, still tired from the long night

He told her, “back to bed, the coffee will be ready soon”

She curled back into his brother that laid with her,

(moving away as he likes to sleep with space..)

He turns his body and mind out to

The phenomenal panoramic view of Los Angeles

Knowing the sun would swim up from the grave

He took in everything he was grateful for,

And exhaled an epiphany of aspiration
Luz Hanaii  Sep 2018
Luz Hanaii Sep 2018
Selfishness is not living as one wishes to live;
Selfishness is asking others to live as one wishes to live."
                                                          ­          Oscar Wilde

This is your life, make it a phenomenal experience.
This reaffirms my belief of "Live and let live."
A good intention can backfire. Don't help the chick crack out of his egg.
sweet dreams to the dismal things
on the shores of an apocalypse
perhaps we are day-dreaming
breathing in these noxious fumes
consuming our own impermanance
is it ignorance of law
or the lure of the commons
that has doomed you
to inhaling all this perfume
threads of light scintillate the moon
an uncommon fuse
forged between your heart and the sun
so come dance and drift
in between rifts of space and time
that melancholy face
oh how i’d love to hold it in my hands
and stand up against you
i never stopped to over-stand you
don't think about it just let it out
before it consumes you
as fast as a spray from a humpback whale
the powers are receding
and we are needing to refill our cups
brunt and blunt like coconuts
what a stunt you pulled
how did you know
that they'd let you get away with it
its phenomenal the mood you instigated
a repatriation of the delegated fields
free of spite and allocated yields
until we became two foolish flowers
that now must die
in order to perpetually bloom
Travis Green Dec 2018
The smoothness of your brown skin
captivates my soul, hazel eyes so bold
and beautiful, a palace of romance and
sensual dreams, shimmering beams and
nightlife gleams.  

His sweet lips touch my skin so
peacefully, melodic vowels and
fascinating sounds, deep channeling
languages of sheer temptations,
harmonic creations.

I can feel the music inside his chests,
the dynamic beats drumming endlessly
around Neptune and Jupiter, explosive
Mars, spinning dynasties over magical

To run my fingers through his dashing
dreads, wavy locks upon my heart,
an aura of celestial instruments
intensifying my flow.

To inhale the lucid lyrics all over
his body, taking in his world of
magnificent nations – the upbeat
rhythms traveling through the
cityscape, the flashing light
posts standing in glorious delight,
the midnight skies of love over
divine cuddling.

The phenomenal poetry gliding
on top of the balcony.  The
shimmering syllables sparkling
in the air.  The brilliant metaphors
bursting in celebration.  The
vibrating alliteration pounding the
pavement.  The swagging similes
dancing in the night.
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