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I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.
KathleenAMaloney Sep 2016
Waste Not True Be
Beautiful Life
Spring From the Rotten Flesh

Seeds Thrown Away
Each One Perfect
Fruit of The Compost
Child
Great Strides
Are Made By Ghes
Who Art Thou?
That Rewrites the Word
By Circumstance
From Free?
Art Thou Free Choice
Given
By Wisdoms Homecoming
We Are Seen
Family of Selves
Throughout The Now
Eternity
Caves Doorway
New Mu Be

Through
The Caghedral
Of Roughen
Loughan's  Blessings
Filled With Nothingness
Light Divine
By Each
Was Life Sprung
Lifting
Our Paris Played Sure
Pain Was But A Virtue
Of Tge Accusation
Came
For To Bless Us
Was Our Crown Made Ure
One Word Ire
That is The Ore
Of Life
One
Onw
Onwards Wford
Ours  is Given Forwatd naught
It's Been  bee as it May
I've Already Been
This Path is Known
I feel It
It's Carriynh me  crow is Hidden  Magic
Many is Me  She My N
N is Majic Magic Magic Magic Magic Magic
K is Chance chance chance chance chance
Choice Choice Choice Choice Choice
Collin CollinCollin Coliin Omire Omeir
One or one ire moire moire moire OMIRE
Omire O Meir.  O'Mire
Omire Where art Thou ?
Cry for You
Cry
Whole
Where Who Where Who My Black Irishman
where
Wisdom
Www Home Wisom
Come Back
Get Me
snakes Sre Gird
Snakes are Ireland
Snakes R Ire
Ire ire ire ire harp
Harp harp harp harp harp harp harp harp
Harp is Me harp is Golden Golden Golden golden golden golden Golden Golden can Play Can Play play Mu Mu mumy my words area
Mu My Mu Mu s mall words
My Name Is George
She King I King  Muse
I King Collin Harpgolden Harp
I King
I King K King K Queen
Golden Harp
King Threads Song Song Sonf song
Threads
Listen
Threads Listen
Song Spiral
Threads listen Collin King Is Song
Jenny
Is
Song
Snakes like song
Call song call song call sing call song call sing
Ask Question Ask
None is Bad
None
Many that don't bro
Belief is true
God is Goodsnakes R Good


Harp Harp
Harp is me Harp is Thread Harp
Mateuš Conrad Jul 2018
/              i play a sweet song with a woman's body,
         that's at the centre of the earth...

                     and why do you think they kept
  rule of thumb of harems with eunuchs?
      you really think they had the capacity
                                                for ****** back then?

it's almost hilarious what "natural" selection
isn't, when it is, replica of natural harems...
               notably, with replica,
        replacing eunuchs, with gays, with ******.
      
  
                          and how many people are fooled
by, attempting to concise
the ownership of cats
           as napping,
             half awake...
                      given my cat?
and what i observed?
               you sure, that, they're
not waiting?
         like opening a window?
you sre they're not harrowed
insomniacs?!
   they always "appear"
to be "sleeping",
  but the, "to be" can sometimes
mislead the concept of
the noun, from the verb...
   to be honest?
      i find my bonsai feline, companion,
to be... a "little bit"
  sleep-starved...
   hence his thespian attitude
in faking sleep...
  or at least acting out sleeping...
    only women shower
reincarnation gifs (promises)
  on cats...
    throw a dog a bone
and let's be over and done with...
can't mortality be mutually inclusive?!
id est:
   mary nichols said (a),
        michael faraday said (b)?
good to be considered
as the anti-thesis of
                      jacob, the tailor,
or cobbler,
  or whatever the criminal term
for ripper actually means...
it's a slang term...
   because what i did with
              the bulgarian prostitutes?!
my affair:
        you get to watch ****.
it's the tattoo of flesh on flesh!
           an inking via tooth!
such trivial pleasures,
  which amount to so much,
and yet...
           experienced with so little
time.
   all of space to be bewildered by,
could not confine man into being,
a man:
   given the temporal allocate-,
             being so...
unworthy of breeding kings...

pauper time!
                  pauper time!
              **** it...
    and the time we have left,
                         not lost to craft a lament?

how to "steal" a kiss from a *******...
how's that?
   oh... you're not a bulgarian
lying about being romanian...

           see you... whenever.

- and yet...

  mmmmmmmmmmmmmmmm...

that folding leg on my body,
that perfume of hair...

     all is and all is lost:
and all is gained...

            with that single, heretical
embrace...

              i spoke of an apple,
i ate a pear,
       but i embraced a peach...
    squish and all "magic": ****! gone!
fly my little dove,
into an embrace of, another...

        but being 2 years apart from
experiecing another human body
to be so intact within such
                    confines of intimacy?

(press me on the ****** /
pervert case)

       flesh qua food:

            which you preserve yourself
from infringing
                       a "desire" to ingest!  
oh mirror that: memory!
                  touch of a tombstone!
touch of the socio-economic
                                       vernacular!      

let me revise that one saying:
               i don't write horror novels...
                              
                        ­                         i am horror.    

- - - - - - - - - -

so reiterate the part where i'm
supposed to "feel" jealous...
    while i tell you, about the, "scraps"
          of loitering with bulgarian girls in
the, "meat market"...

              **** have a madonna
shoved up in there to boot?!

                **** me!

                                     WINNER!

at least she has a mandible leg
to attach itself to my torso,
and spin a metaphorical
               spiderweb around it...

as i allowed myself to pluck
her previous four ******* etc. examples
                  with my lips...

tooth, by tooth, by tooth,
by even more the suckling
             inertia
       of lip, upon lip, upon lip, upon lip:

and so...

                                  S

but she is... what was already given...

    a lightning storm and a naked
                                       body in a mirror!

your people have ****,
   why can't i, have my desired outlet?
the dutch would be sensible enough,
not to allow such a flamboyant
narrative, continually imploding...

             but the english will;

i.e. the, "naughty" sentiment of
the non-distrubution of "information"...

      excessive potency of marijuana
in the skunk format...

                     well?

                                                     applause!

don't worry, i'll ******* with you
                                    but my hand is... sort of:
non-synthetic...
     so i guess, given your soft pouch of genitals,
i'll have to imitate ****.
                                           /
Tiffany Marie Dec 2014
Me and ember
Are together
We are the
Best of friends
She and me
And the world we see
We sre alll
together
Me and ember with
Not a single
Diasaster
And if there
Was it wouldnt
Matter cuz
We together won't hurt a soul.
Then again we best friends
And neither will it burn a hole
cuz. We are full
Me a double e. Are
Totally happy
For me to and double e to enjoy
One simple word
brought 6 years back to me
thought I had released it all
thought I was free
Memories and feelings abound
but must remain silent
too much life passed by
as it probably was meant
I now wonder about old age
and how it'll be
will it be pine and fir
or a red rock sea?
I don't know why I wonder
I'm sre they'll be no change
so put te silent feelings
our of my hearts range
Be happy with all the memories
and that which I've seen
and be thankful in your soul
for all that it did mean
Jonny Angel Jul 2014
The skyline's changing,
there's a condominium
built up on the lake,
at our secret place.
the place where
we held hands,
first kissed
& skipped stones
& wished on falling stars,
where I found my first arrowhead.
Some of the best places
sre long gone....
and my heart cries
on your sweet memory.
Canberra Canberra the team to beat they won 3-1 in the last to bring them to the grand
The crowd in Perth are very sad
Canberra are through to the grand final against Brisbane
Everybody moves everybody grooves
Canberra are the best
And they are prepared to say
Bring on Brisbane beat the bandits
The cavalry are playing well
And they are still apart of the comp
You see as the pitcher pitches
The ball to try and defend this little lead
Go the mighty Canberra
Rah rah rah
Come on Canberra
The fun is just beginning
The championship is just around the corner
Let’s get down and boogaloo dudes
GO CAVALRY there is a little queen song which will
Get you through
Cavs are the champions we hope
They sre only 3 or three wins away so cool
Cavs are the champions
They are the mighty Cavalry
The grand final has one of your hands on the trophy let’s make it two


Sent from my iPhone
My ears are covered, yet the screams sre louder
The world is paused, but somehow moves faster
I closed the book, but the end's coming sooner.
I never saw a butterfly, and I've never seen a beginning. There is only a strange circle of workong out. We all lose. I am no great man and my life was a lie
jeffrey conyers Jul 2019
We hear it?
We see it.
Many believe it.
America held me back.
Sre racism exist.

One race, depending on your view.
Profit greatly from this.
Except, we aware of many with jobs?
Got this through a family connection.

We hear it.
We see it.
Many believe it.

Some races depending on your view.
Think, they still entitle.
Except, many of are surrounded by many not qualified for that field.

We see it.
We know it.
And speak to others about it.

Except success is based solely around your determination.
And where else?
Except, in America, are you about to be anything.
jeffrey conyers Aug 2018
So another coach is facing drama for his defense of holding back knowledge of a coach with domestic violence allegations.

Why?
It's better to advise him to seek counseling and alerts higherups of the abuse.

No championship is worthy of hosting higher.
If scandal derailed it.

Sre, this fabrication I knew nothing about it.
Remind many of coaches hiding child abuse.

Does any head coach get it?
Or coaches in general?

Now, your legacy is blemished because of your own decision.
We have heard turn a blind eye and you got no reasons to complain.

When it ruins your so-called good name.

— The End —