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I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.
I've been acquainted with the following
psychoactives compounds:

Depressants & Dissociatives;
Ethanol / EtOH / alcohol, drink, *****
γ-Hydroxybutyric acid / GHB / G, fantasy
β-Phenyl-γ-aminobutyric acid / PhGABA / Phenibut
Dextromethorphan / DXM / Benylin, Robitussin
Morphine / Papaver somniferum / *****
3-Methylmorphine / Codeine
Dihydrocodeine / DHC
Buprenorphine / Subutex, Suboxone
N-Allylnoroxymorphone / Naloxone / Suboxone, Narcan
Tramadol / Ultram
O-Desmethyltramadol/ O-DSMT / Omnitram
Thiopental / Sodium Pentothal
Diazepam / ******
2'-Chlorodiazepam / Ro5-3448 / Diclazepam
4'-Chlorodiazepam / Ro5-4864
Chlordiazepoxide / Librium
Gidazepam, hidazepam
Desalkylgidazepam / Bromonordiazepam
N-Desalkylfluarazepam / Norfluarazepam
Flubromazepam
Alprazolam / Xanax
Bromazolam / XLI-268
Clonazolam, Clonitrazolam / Clam
Etizolam / Etilaam, Etizest
Flualprazolam
Flubromazolam
Zopiclone / Zimovane
Pagoclone
Promethazine / Phenergan
Diphenhydramine / DPH / Benadryl, Nytol
Chlorphenamine, chlorpheniramine / CPM / Piriton
Cetirizine / Zyrtec
Amitriptyline / Elavil
Tianeptine / Coaxil, Stablon
Mirtazapine / Remeron
Quetiapine / Seroquel
Nitrous Oxide / N2O / laughing gas
Amyl Nitrite / Poppers
Ketamine [racemic] / K, Kitty
Esketamine [S-isomer] / Special K
Deschloroketamine / 2'-Oxo-PCM / DCK
N-ethyldeschloroketamine / 2'-Oxo-PCE / O-PCE / Eticyclidone
Deoxymethoxetamine / 3-Me-2′-Oxo-PCE / DMXE
Methoxetamine / 3-MeO-2'-Oxo-PCE / MXE / Mexxy
Hydroxetamine / 3-**-2'-Oxo-PCE / HXE / Hexxy
Methoxpropamine / 2-Oxo-3'-MeO-PCPr / MXPr
Methoxisopropamine / 2-Oxo-3'-MeO-PCiPr / MXiPr
3-Hydroxyphencyclidine / 3-**-***
3-Methoxyphencyclidine / 3-MeO-***
3-Methoxyeticyclidine / 3-MeO-PCE
3-Methyleticyclidine / 3-Me-PCE

Stimulants & Enhancers;
1,3,7-Trimethylxanthine / Caffeine / Coffea, Camellia sinensis / Coffee, Tea
3,7-dimethylxanthine / Theobromine / [constituent of] Chocolate
N-Ethyl-L-glutamine / L-Theanine / [constituent of] Green Tea
Nicotine / Nicotiana / Tobacco, cigarettes, smokes
Ephedrine / Ephedra
Pseudoephedrine / Ephedra, Sudafed
Adrenaline, Epinephrine
Choline bitartrate
L-alpha glycerylphosphorylcholine / Alpha-GPC, Choline alfoscerate
Cytidine 5'-diphosphocholine / CDP-choline, Citicoline
N-Acetylcysteine / NAC
2-Dimethylaminoethyl (4-chlorophenoxy)acetate / Meclofenoxate
N-Phenylacetyl-L-prolylglycine ethyl ester / Omberacetam / Noopept
Coluracetam / BCI-540
4-Phenylpiracetam
Propranolol
(±)-2-Benzhydrylsulfinyleth­anehydroxamic acid / Adrafinil
(±)-2-[(Diphenylmethyl)sulfinyl]acetamide / Modafinil
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide / Armodafinil
α-Methylphenethylamine / Amphetamine, αMP / Speed
N-Methylamphetamine / Methamphetamine / ****
Lisdexamfetamine / Vyvanse, Tyvense, Elvanse
2-Fluoromethamphetamine / 2-FMA
3-Fluoroamphetamine / 3-FA /  PAL-353
4-Fluoroamphetamine / 4-FA, 4-FMP /  PAL-303 / Flux
4-Methoxyamphetamine / PMA, 4-MA / Death
5-Methoxy-2-aminoindane / MEAI, 5-MeO-AI / Chaperone, Pace
Methythiolpropamine / MPA / Blow
3-Fluorophenmetrazine / 3-FPM / PAL-593
Methylphenidate / MPH / Ritalin, Concerta
4-Fluoromethylphenidate / 4F-MPH
4-Fluoroethylphenidate / 4F-EPH
3-Methylmethcathinone / 3-MMC / Metaphedrone
3-Methylethcathinone / 3-MEC
4-Methylmethcathinone / 4-MMC / Mephedrone
4-Methylethcathinone / 4-MEC
3-Chloro-N-tert-butyl-cathinone / Bupropion / Wellbutrin, Zyban
4-Chloromethcathinone / 4-CMC / Clephedrone
4-Fluoromethcathinone / 4-FMC / Flephedrone
4-Fluoro-α-methylaminovalerophenone / 4-Fluoropentedrone / 4-FPD
α-Ethylaminocaprophenone / N-Ethylhexedrone / NEH / Hexen
alpha-Pyrrolidinohexiophenone / α-PHP / PV-7
alpha-Pyrrolidinoisohexaphenone / α-PiHP, α-PHiP
3,4-Methylenedioxy-α-pyrrolidinohexiophenone / MDPHP
3,4-Methyl​enedioxy​pentedrone / βk-MBDP / Pentylone
3,4-Methylenedioxymethcathinone / βk-MDMA / MDMC / Methylone
3,4-Methylenedioxymethamphetamine / MDMA / ecstasy
5-(2-methylaminopropyl)benzofuran / 5-MAPB
6-(2-Aminopropyl)benzofuran / 6-APB / Benzofury
6-(2-Aminopropyl)-2,3-dihydrobenzofuran / 6-APDB / 4-desoxy-MDA
Mesembrine / Sceletium tortuosum, Kanna
Harmine / Peganum harmala / Syrian Rue
3,4,8-Trimethoxyphenanthrene-2,5-diol / Dendrobium nobile
NSI-189
4-chloro-N-(2-morpholin-4-ylethyl)benzamide / Moclobemide
Escitalopram / Cipralex, Lexapro
Fluoxetine / Prozac
Sertraline / Zoloft
Venlafaxine / Effexor
5-Hydroxytryptophan / 5-HTP / Oxitryptan

Hallucinogens & Psychedelics;
Cannabidiol / CBD / Cannabis
Cannabigerol / CBG / Cannabis
Δ9-Tetrahydrocannabinol / THC / Cannabis, Marijuana
Hexahydrocannabinol / HHC
AM-2201 / Synth-'noids, Spice
NM-2201 / CBL-2201
5C-AB-PINICA
Salvinorin A  / Salvia Divinorum / Diviner's Sage
d-Lysergic acid amide / d-Lysergamide / LSA / Ergine
Lysergic acid diethylamide / Lysergide / LSD, LAD / Acid, Lucy
Lysergic acid 2,4-dimethylazetidide / LSZ / Diazedine, Lambda, λ
1-Acetyl-lysergic acid diethylamide / 1A-LSD / ALD-52
1-Propionyl-lysergic acid diethylamide / 1P-LSD
1-Cyclopropionyl-N-Methyl-N-isopropyllysergamide / 1cP-MiPLA
6-Allyl-6-nor-lysergic acid diethylamide / AL-LAD / Aladdin
2,5-Dimethoxy-4-methylamphetamine / DOM / Dominic
2,5-Dimethoxy-4-bromoamphetamine / DOB / Aphrodite
2,5-Dimethoxy-4-chloroamphetamine / DOC / Doctor
2,5-Dimethoxy-4-methylthioamphetamine / DOT / Aleph
2,5-Dimethoxy-4-methyl-α-ethylphenethylamine / 4C-D / Ariadne
2,5-Dimethoxy-4-methylphenethylamine / 2C-D, 2C-M / Matrix
2,5-Dimethoxy-4-ethylphenethylamine / 2C-E / Eternity
2,5-Dimethoxy-4-bromophenethylamine / 2C-B / Nexus
2,5-Dimethoxy-4-chlorophenethylamine / 2C-C / Callisto
2,5-Dimethoxy-4-iodophenethylamine / 2C-I / Infinity
2,5-Dimethoxy-4-methylthiophenethylamine / 2C-T / Tesseract
2,5-Dimethoxy-4-ethylthiophenethylamine / 2C-T-2 / Rosy
2,5-Dimethoxy-4-fluoroethylthiophenethylamine / 2C-T-21 / Aurora
2,5-Dimethoxy-4-bromo-β-keto-phenethylamine / βk-2C-B
2,5-Dimethoxy-4-bromo-β-hydroxy-phenethylamine / βOH-2C-B / BOHB
2,3,6,7-Benzo-dihydro-difuran-8-bromo-ethylamine / 2C-B-FLY
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-bromophenethylamine / 25B
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-chlorophenethylamine / 25C
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-iodophenethylamine / 25I
2,5-Dimethoxy-N-(2-hydroxybenzyl)-4-ethylphenethylamine / 25E-NBOH
3,4-Methylenedioxyamphetamine / MDA / Sass, Sally
3,4,5-Trimethoxyphenethylamine / Mescaline / M
3,5-Dimethoxy-4-ethoxyphenethylamine / Escaline
3,5-Dimethoxy-4-methallyloxyphenethylamine / Methallylescaline / MAL
α-Methyltryptamine / αMT / Indopan
N,N-dimethyltryptamine / DMT / The Spirit
N,N-dipropyltryptamine / DPT / The Light
N,N-Diisopropyltryptamine / DiPT / The Sound
N-Methyl-N-ethyltryptamine / MET / The Colour
N-Methyl-N-propyltryptamine / MPT
N-Ethyl-N-propyltryptamine / EPT
N-Methyl-N-isopropyltryptamine / MiPT / The Touch
4-Hydroxy-dimethyltryptamine / 4-**-DMT / Psilocybe / Psilocin
4-Phosphoryloxy-N,N-dimethyltryptamine / 4-PO-DMT / Psilocybin
4-Acetoxy-dimethyltryptamine / 4-AcO-DMT / Psilacetin
4-Hydroxy-N-methyl-N-ethyltryptamine / 4-**-MET / Metocin
4-Acetoxy-N-methyl-N-ethyltryptamine / 4-AcO-MET / Metacetin
4-Acetyloxy-N,N-dipropyltryptamine / 4-AcO-DPT / Pracetin
4-Acetoxy-N-methyl-N-cyclopropyltryptmine / 4-AcO-McPT
4-Acetoxy-N-methyl-N-isopropyltryptamine / 4-AcO-MiPT / Mipracetin
4-Hydroxy-N-methyl-N-isopropyltryptamine / 4-**-MiPT / Miprocin
5-Methoxy-N,N-dimethyltryptamine / 5-MeO-DMT / The God, The Power
5-Methoxy-N-methethyltryptamine / 5-MeO-MET / The Vision
5-Methoxy-N,N-diallyltryptamine / 5-MeO-DALT / Foxtrot
5-Methoxy-N-diisopropyltryptamine / 5-MeO-DiPT / Foxy
5-Methoxy-N-methyl-N-isopropyltryptamine / 5-MeO-MiPT / Moxy
Each of our interior universes differ, their exploration is not a competition.
This list is merely a personal reference for my own psychoactive history.
I have come to disavow psychonautics in favor of phenomenology or philosophy of mind.
Nathan MacKrith  Dec 2018
Selfie
Nathan MacKrith Dec 2018
I will have you know that you are in the mine-ority
If you don’t look at my pic and insta-click “like” on me
I thrive in this weblight, you subsist in ambig-you-ity
Mine is the looking glass of Aphrod-I-te
The un-My-ghty look on my aesthetic perfection and despair

I am the reason there is an earth
All was designed to usher in my triumphant birth
You are just hateful ab-you-sers and mis-you-sers
YOU are YOUVENILE YOULINQUENTS!

I am the oh-so-fleeting truth  
Present in a world obsessed with youth
I am only worth what others see in me

I embody the my-jority
My onscreen attention antics
Are the me-ssential components
Required to build a thriving Me-ocracy.
~
NM  
10/17/14
presented as part of a Dawkins’-meme based poetry collection at the 2019 “Trash Talkin’” literary Conference at the University of Regina, in Regina, SK, Canada
kalpana nayak Jun 2015
Jee aur aieee k sadme k mare ** jte h anjne anokhe unvrsts k hawale,nya clg nya jgh nye dost sb kch hta h nw nw,clg k strtng s hr ksi k dil m hta h rgng ka dar....2nd yr m cnr bnne ka hta h sbko gurur,frnds kai grp m bat jte h,hr koi dkhte h nye luks m,3rd yr m sbko ati h apni jimedari ka ahsas aur fnl yr ata h dston m fasle bdhte h...rah dkhe the is din k kbse,age k sapne saja rkhe the njane kbse,sb bde utavle the yhn se jne ko,zndgi ko dusre trke se dkhne ko....pr njane aj dil m kch aur he ata h,piche ja k waqt ko rok k apne andr sare lmhe ko samet lne ka jee krta h....at d strtng f btech kha krte the bdi muskil s y 4 sal bitenge lkn kse pta tha y sb chd k jne ka mn ni krga...na vulne wali kch yadein reh *** o yadein jo ab jine ka sahara bn ***...na jne aj q un palon k yad bht ati h jin baton ko lekar tab rote the ,aj un palon ko yad kar bht hsi ati h....y sch k ankhein nam ** jte h k mri tang ab kn kncha krga,m apne bton s kska sar khaungi,pranks ksk 7 krngi,ab mjhe kn itna jhlga,ksk smne ntnki krngi,jin dst p lakh kurban whn 1 rupye k ly  kn ldhnge,kaun rat vr bina soye bt krga,kaun bina pche 1 dusre ka chj istml krga,kaun nya nm rkhga,bina ksi bt k m ab ksse ldhungi,bina ks tpc k fal2 bt kn krga,bkws q kn krga,xam k ek din phle o tyri o rate,kn rat var 7 jag kr pdhga,kn fail hne p dilasa dlyga,y hasin pal ab ksk 7 jiungi....yad ati h o rec k choti si cntn bar bar jhn kch v ni mlta mre yar fr v na jane q hum gye hnge so bar...tum jse kmine dost khn mlnge jo khai m v dhaka de ayen sale srs mtr ko v joke m cnvrt kr de,par fr tmhe bachane khud v kud jye....mre hrkton se nakhro se jid s prsan kn hga ,ksk 7 brng lctrs jhlngi..bina mtlb k ksko v dkh kr pglon k trh hsna,na jne y fr kb hga....ky hm y sb fr krpaenge....bdy clbrt,ek h rm p bth k 1 dusre s wtsap p bt krna...rat k 3-4 bje khna pkana....bina ksi mtlb k rat ko chilana....mlk pina...pgl jse hrkt krna..mlk ghumna....kaun mjhe apni kabiliat pr vrosa aur jyda hawa m udne pr zamin p lyga....mre khusi m sch m khus kn hga,mre gam m mjhse jyda dukhi kn hga....keh do doston y dubara kb hga....dil m ek kasak hoti h jb hr ankhein nam hti h,fir mlne k wade se hm ek dusre se juda hte h,kv na akle rhne wle dost bas yadon k sahare zndgi bitate h....lkn jb v y clg k din yad ate h ankhon m hasin aur ansu ek 7 late h...engnr bnne k khusi v ansu rok na pai ,q k njr aa rai t doston s judai...ab jo hna tha o ** gya akhir m sbse juda ** h gye....aj v un palon ko yad kr k ansun rok ni pte h ....nkl he jte h...aur yuhi lkh lkh k apko pka rai hn....char sal yu he gye hmri beet..ab khn mlnge wo dost wo mit...dua krt hn sb k ly race y zndgi k jao tm jit....
I ms my clg clg dys.....
Nathan MacKrith Dec 2018
The Revolution will not be pay-per-view,
Streamed online, or listed in the TV Guide,
The Revolution will be LIVE ON AIR
Rush seating No reservations First to come are first to serve
The Revolution will not be monetarily politicized,
the Revolution will be patronized

Next, On the World Today Network: Revolution This Way Comes

The Revolution will not be a mutually exclusive for
CBC, BBC, CNN, YouTube, Facebook, SnapChat, or Instagram
The Revolution is more than digital trolling,
It will be a Counter-Electronic-Magnetic-Pulse

Do you have your passport for the Revolution?

The Revolution is unauthorized
Written for and by all the people
The Revolution is radical, hands-on, and requires assembly
Batteries are not included and there is no manufacturer’s warantee,  
The Revolution will be uncomfortable for those living in leisure
For it has been bred to cause the Elite displeasure

Revolution 99% Uploaded
Press [ENTER] key to initiate collective action
~
NM 10/17/15
*After Gil Scott Heron's epic "The Revolution Will Not Be Televised"

— The End —