numerous books and songs
have been written about it
and when spelling it you'll
require oodles of wit

its location is in
the northern hemisphere
and cotton and corn are grown
within its very sphere

it is seen to branch
into feeder streams
at the end of its long
interstate traveling gleams

slaves were transported on ships
to toil near the river's banks
and their colonial masters gave
them such meager thanks

the I's and the S's
get much mention in its name
so are any of you able
to figure out its game