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You can find my poetry book, MIND AFIRE on Amazon if you are interested in my further works Other than that I am a songwriter, …
Poems
Mydriasis Aletheia
Sep 2016
like know just time mind life feel world lost say we're things think love there's does people night away way thought got words long reality want better left make end eyes day man human dark experience remember really right death memory going place high good live city thoughts soul meaning great pain home sky believe shall change living oh fall light choice god consciousness existence years cause hard feeling thinking fear times 'cause dreams ask alive heart need past felt days dream sensation truth true use power knowledge wrong stars understand baby tell state thing face wave broken old you'll wave new broken nature you'll **** mental look far ah drug moment best ago air lose sleep dare try leave beautiful blue born lives escape sublime doesn't body dawn friends waiting feels young daze game control perception gone story mean sun head given writing act difference reason poetry philosophy psyche little trying touch deep greatest wonder choose drugs exist we'll moments score hold play set run self forget coming hope word future dead wish burn music emotion rain stop gaze pleasure glass one's what's lies sense wake hit remain real work bad stay open brain art seek space present happy spent acid pill social we've they're half-light used land held gotta help lie path finally listen actually longing rave water cold seeking caught energy reflection information anymore venturous goes came red hide start truly hand evil divine subtle matter kind lonely yes told eternity keeps line black edge ego context dusk horizon gonna spiritual tripping dimension data die white **** seen means care getting saw places sure freedom looking hurt fool wind flow search chance la took broke existential summer content flowing belief praise empyrean empathy discovery chemical aeon couldn't who's turn forth bit question eye judgement pray passion sound personal worth memories sanity accept universe embrace lack knows free makes rise language decide consider temporal society gain wander conscious stuff religious comprehend particle psychedelic metaphysics you've entheon absurdia entactus maybe ready fate realize family meant return perfect learn miss spirit doubt rest loved minds health moving mortal bring expression sleeping cast lines purpose quiet known strange infinite king months madness haze depths ate party patterns oneself psychedelion inside guess crowd later silent clear soft breath hours hate dust forgotten arms drink fast year war longer close searching morning ashes calm beauty darkness different justice fell friend shadows knowing fine youth heavy standing sweet enjoy explain vain simple chasing hidden ends smoke gold heaven follow point person breaking necessary today relief action cool possible bass generation lying listening machine yeah substance hath engine forlorn problem subject intangible study effort quantum definitions dopamine psychedelics we'd sigma cybran apotheon isn't empathion clouds practice gave warm wanted stand poem wait storm met asleep course skies crime surely grow depression write loose fair ecstasy knew dreaming humanity waves share taken simply faith playing sands view fix winter afraid began wise welcome comprehension sought late big zero table says bliss changed repetition everybody blame unto maze understanding mr explore states ignore addiction venture define teenage american humans billion she's wasn't 'til sonder walk smile tonight speak dance skin blood breathe fears illuminate worse peace girl crave easily emotions feelings **** having force ways lets catch meet hair doors worlds hearts destroy heard walking near hurricane wisdom lights second suicide ignorance fresh waking sadness grand happiness appear rising scared save join adventure neon outside alike liberty particles wonderful compounds killed somebody grace merely closer company desert master twisted realm respect trance ridiculous *** exile pondering noble dangerous absurd nation progress culture contradiction perceive irish urban phenomena cyberspace scoreboard psi ain't you'd mydriasis entheogenesis **** ones taste throw watch painting room alas lay history spend apart sea staring poet fact cut smell happened admit river wasted brought leaves making answer sorry glow learned decided grasp breeze bed begin pretty floor lived sole sand cure awake sight tears barely kept running safe roam willing prefer mist heads asked prose wandering sounds imagine looked hour growing recognize soon falls mirror treat ***** brother climb hero problems granted digital proud changes birth quest age spring aware doing witness names amazed ****** despite takes condition intoxication level beginning worked pupils decision object insanity rhythm medium quality weather physical false process strife individual journey doth code effects abandoned channel judge notions moral swear experienced greater chain natural thunderous cleanse determine shivering hallowed plus reckon caused adolescence media superposition addict connection indigo ethics survived definition reasoning internet feedback vibrancy serotonin cyclone hacker sardonic surreality virtuality here's he's sunyata temporality ******'s empathos apotheotelos flash shining green forever anger carry son moon selfish written supposed feed ya quite loop hooked pure feet hole paper flag sick voice burning attention fly utter wicked tremble endless form infinity talking piece shores verse chest rules food placed plan hallelujah called gun fading drinking emotional measure inspiration suffering belong west read sly instead bear erase furious shame conclusion drunk roll ******* depressed calls taught died defined tire everyday answers sacred acknowledge speaks perfection games ground spoke stood motion sway keeping pretend hell movement magic park key spin kick sake jump hanging animal begins orange streetlights fade crazy honest warp puppet chained survive apathy chains claim prey science diamonds begging grip tale hang powerful wonderland heal dealing plant twice painful daylight mastery desires recall school conviction miracle yearn empyreal weekend actual court value chalk hurts humankind rabbit eggs potential offers temporary pupil atlas nostalgia serenity happens yearning ponder hypothesis worthy witnessed ideas azure tools alpha curiosity consume singularity typhoon revelation stimulant liberate application projection criminals communication throes fraternity enables actuality starshine ethos apotheosis sardonicism aren't mind's teleology empatheon entheos hear mydriatic transcendention fight tear ash minutes wanna taking nights forgot tales lest desire lust darkest single shine slow allow destruction money comes anxiety contemplate nostalgic offer continue happen ink brings brave created holding create thunder produce talk sail philosopher creating distant illuminating drive dancing ease wishing higher pass excuse figure essence angel hopes child ahead sigh using door vast loves awaits strong tornado ok sorrow immortal ghosts certain remains stained insane reached lot discovered plain poison streets killing ending tried session vs poor woke stare watching grass slick emptiness falling box painter series children virtues awareness clean rolling reach advice heavens rend half cherish bay started relax focus laughed ashamed fiend melody drop exhale void occurs beneath win chose robes thrall shield ended sons normal sunrise road forged onward burden actions unlike colors curious street observe chosen silence shades returns technology race vengeance swept bag civilization strive reconcile trouble cloud described replaced substances whilst finding euphoria dear chemistry events deal message eternal masses beliefs vision apparent honestly dr seeing idea domain soar books frames rule law pleasures eat dread bare blaze raise compassion kindness wandered objects expressed sin declare mistake smoking drum heavenly honor lands fountain renew happening aspect gotten issues divinity teach matters pills goal follows significant job romantic gazed envelope elements identity group sell foolish lucid dimensions brothers owe education november difficult recognition express properties glitter considering illusion appreciate discover resonance derived transcendental buzz notion risk scares riot rainy teaching drizzle direct experiences elation normality quote evolution versus lamplight method reflective endeavour cloth eats teenagers eventually haul club result relative breed threat subjective concerning solstice interpretations allows rational ultimately basis aligned numbness hypocrite charade morality dope chaser continuum undead exploits aeons research freeman appropriate ion ****** teachings dilation binge beatific intuitive transcendent escapism psychedelia metaphysical beta untitled mescaline otherworldly dreampt contextual experiential symbiosis codex dissociation cybernetic weren't life's let's mirror's well-being any-more entheogenic junkiedom signifiers mescalito zero-summing won't 'pataphysics window million pair logic alright whisper stone walls notice fun picture lips whispering dying wanting hands pull remained pieces poems built push house choices united turns blessed lucky drifted sane demons demon external slowly worst angels town needs needed drifting watched abyss crimson liquid arch planes add souls questions leads flicker thousand swallow note strings player despair offering realms drift caressing enter gentle closed bodies letter beat gorgeous indescribable smiling laughing probably pick grown shade precious shooting background yesterday woman ocean sober lead clothed ghost flows turned conscience alphabet contain spun luck atmosphere vagabond completely surprise rock creed drawn book autumn rays spinning bottle early regrets lake kids sad acceptance stuck melancholy formed slip draw clearly scars collapse del sit satisfied jungle realized bunch favourite laid fit breaks notes plans anyways spoken produced echoes den trees steps ugly cover explained glance stole gazing current raised travel scratch haunts played women apathetic conquest naught goodbye midnight asking passed waste loss fallen rapture absolute positive walked mistakes lately bound patience nurture fog stranger men wants prevent forfeit asks arose easy quick sing allowed prove pitch mad closest deeply tides praying root poets sentence pulse nightmare deem coffee commit golden insert mock innocent whispers offend low tea strength captured attack stories baseline joint innocence neural chemicals plains blanket dripping reflect blink concepts psychosis plucked tidal radiance roar bathed wonders thrown moves suffer unspoken exists glad shroud plunge scorn bane asunder enslaved harvest possibly fail allure drank danger unsaid veil gravity assume sum receive bloom reveal odd whispered likes news fractured wisely gathered seraphim intention wrought plane weeks mere haunting aspects ha distance hungry eternally swaying eden foretold breach advance pains balance design event forgive significance confidence error alter paying unreality cost chronology thoroughly resembles vivid steal poetic illegal understands maelstrom temples amidst perpetual lesson pathos behold reborn produces scale heaviness ascend talked **** forsake valuable andor relinquish dismiss usually kid nervous sort fierce disguise demands abandon encourage avoid minor relentless identify loneliness web alchemy cosmic rhyme coil suffered basking dropped standard spark mates hearth swore steam myth native wonderfully occasionally solace ventures determination galaxy opportunity justify political prophecy steadfast healthy forsaken chapter facebook worried ex struggle shatter gentleman including convinced profit comfortable twine deity responsible adrift sage fortune immortality theft damage examine deliverance ultimate immersion response access test physics magnitude occur member relation acts theme signal shivers mire coin planet anybody vicious nirvana pendent applause glimmering benediction consuming glint refrain renewal myths manifest nocturnal reflections limitations teenager naturally material matrix columbine giveth inseparable singular proving lifestyle coherence humane ideals starlight sincerely prudence underworld infamous perspective presented pretends excitation viewed regard enhanced zen reverence arcadia theory realization typing construct statement subjugated exploration vote hazy reaper **** streetlight artificial trespass definitive device exceed complex finality surreal petrol proposition inspiring totality originally recurring narcotic cometh juxtaposition reckoning represent inability proclamation syntax continuity nevermind avoidance irrelevant veracious arcadian commence rumination aesthetics ubiquitous nonetheless variable exploit experiencing underlying villain cola rictus ketamine corporeal electronic graciously input cannabis manifestation comprised socially proportionate insofar ethical hedonism junkies vicissitudes cognitive determining psychiatrist palindrome lucidity remix reduction dissociative reclamation detract aer enhancement intoxicants qualia world's shouldn't wouldn't other's nothing's man's summer's today's who'd everybody's y'all 'the all's t'was ethereality thought's drug's noumenon skystruck shroom alexithymia transhuman you- -the in-between self-sufficiency -one zed's 15 11 liminality immanence adrenergic symbionts sublimeoblivious medina's buckfast psychonautes determinative serotonergic psychedelos skyglow cyclica 5-ht2a noumena pharmahuasca jeans role proper loud aching grows concrete cruel strains conversation ill paint wet couple calling mouth kiss senses case keeper torn pause middle setting whats pulling bone reminds likely remind wrath karma reading sunlight prone ***** phrase enemy familiar levels careful source adolescent small straight driving courage rush flaw suppose starting deny stayed weary worship trust turbulent troubled letting absence leaving wearing college proclaim spirits gather ear lady hey garden boys winning alcohol pay foolishly banish song cross encounters plays belonging famous shift burst alice tunes hood flickers glimpse gleam fleeting grant ride deja vu anticipation spot switch boyfriend order faded wrapped definitely short fish beach clock older dusted block station anchor longest deserve passing mark awhile lovers muse ache island totally existing comfort pride phone greek apollo bleeding unknown psychic powder remembrance tree train helps painted gambling tide tired acting blow build apologies silver fabric especially suspense band cascade flawless heat hunger nearly numb bread bright minus wide looks differently dive beating veins settle turning couch holds saying impression suspension meaningless plastic rich pointless occupied brief tiger sticks stones mask cake bitter concentrate drown forbidden shell dry walks unless regardless moved type shirt lone burns songs negative momentary staying police swing unseen ability analysis worries determined dreamt sink hopelessly chances abuse palm week existed ignorant blind dice sheep agree joke spy spill odds immeasurable *** pushing wanderlust softly midst presents blade guided ripped round ball lovely rhythms beats cars glaze wash fates evening vein gloss juvenile sides faces graces month circular rung wheel rises permeates father supreme portal liked rip fades october sitting grin showing surrounded explored opened confused wall quietly deftly scene sighs lingering radio altered evaporated suns dreamed vibration important appetite exactly devil inhabiting brains ordinary beckons constant local organic soothing linger meditation moonlight lads height ethereal simplicity kinda cigarette suggest violence blew bombs arise trips predict surface guy movements grey car stepped large bank forward landed lied ancient purely crash direction inspired release warned melodic rhythmic telling mysticism blues riddle blur floating drama neck lover nerve poisonous glare factory wage character suburbia escaped gates suspended followed pierced hall marks ruled influence functioning contained losing stopping effect electronica relate fed temper facts dependent malleable convey bent delve horror wolves won lacking certainly fooled temple oblivious watches extension molecular random subtlety rem price sear covers truths judging stage frost conditions victory millennium realised confront trickster eve daughter defines awoke terror remembere
Composed on 00:53, 21/09/2016 using Hello Poetry's 'Words' algorithm. We don't assume this means something.
Kendall Mallon
Jul 2013
Book One
Prelude:
As Romans before them, they built the city upward—
layer ‘pon layer as the polar caps receded
layer by layer—preserving what they could, if someday
the waters may recede back into the former polar
ice caps; restoring the long inundated coastlines.
Home:
A man sat upon a tall pub stool stroking
his ginger beard while grasping a pint loosely
in his other hand. An elderly gent stood
next to him. The older gentleman noticed
that the ginger bearded man’s pint sat almost
quite near the bottom of its tulip glass.
A woman with eyes of amber and hair
as chestnut strolled through a vineyard amongst
the ripening grapes full of juice to soon
become wine. She clutched a notebook—behind (10)
thick black covers lay ideas and sketches
to bring the world to a more natural
state—balancing the wonders and the merits
of technology apace with the allure ‘n’
sanctity borne to the natural world.
When the ginger bearded man finished the
final drops of his stout, another appeared
heretofore him—courtesy owed to the elder
gentleman. “Notice dat ye got d’ mark
o’ a man accustom amid the seas,” (20)
he inferred; gesturing the black and blue
compass rose inscribed inside a ship’s wheel,
imbedded into the back of the ginger
bearded man’s weathered right hand.
“I have crewed
and skippered a many fine vessel, but I
am renouncing my life at sea—one final
voyage I have left inside of me:
one single terminal Irish-Atlantic
voyage t’ward home.” (30)
“Aye d’ sea can beh cold
‘nd harsh, but she enchants me heart. Ta where
are ye headed fer d’ place ye call home,
d’ere sonny boy?”
“’tis not simply a where,
‘tis a who. Certain events have led me
to be separate from my wife. For five
eternal years I have been traveling—
waiting to be in her embrace. The force
of the Sea, she, is a cruel one. For (40)
it seams: at every tack or gybe the farther
off I am thrown from my homeward direction
to stranger and stranger lands… I have gone
to the graveyard of hell and the pearly gates
of (the so called) heaven; I have engaged
in foolhardy deals—made bets only a
gambling addict would place. All to just be
with Zara. I am homesick—Zara is my
home—it doesn’t matter where (physically)
we are located, my home is with Zara. I (50)
was advised to draw nigh the clove of Cork
and wait; wait for a man, but I was barely
given a clue as to who this man is,
only I must return him this:” the ginger
bearded man held out a dull silver pocket watch
with a frigate cut into the front cover
and two roses sharing a single stem
swirling upon themselves cut into
the back.
“Can it be? ‘Tis meh watch dat meh (60)
fat’er gave t’ meh right before he died…
I lost it at sea many a year ago.
It left meh heartbroken—fer it was meh only
lasting mem’ry of him… Come to t’ink I
was told by a beggar in the street—I
do not remember how long ago—dat
I would happen across a man wit’ somet’ing
dear t’ meh, and I’d accomp’ny dis man
on a journey, and dis man would have upon
‘im d’ mark of a true sailor…” (70)
“Dear elder man,
my name is Abraham; the mark you see
represents the control that I have on my
direction—thought it appears the Sea retains
some ascendancy… Yet now, it appears,
the Sea is upholding her bargain—though
a bit late... Do you, by chance, own a vessel
that can fair to Colorado?—all across
this mist’d island no skipper ‘ll uptake
my plea; they fear the sharp wrath of the Sea (80)
or (if they have no fear) simply claim my home
‘is not on their routes…’ i’tis a line I’ve
heard too often. I would’ve purchased a vessel,
but the Sea, she, has deprived me completely
of my identity and equity.”
Zara, with her rich chestnut hair sat upon
a fountain in a piazza—her half empty
heart longing to savor the hallow presence
of Abraham, and stroke his ginger beard…
Everyday she would look out at the sea (90)
whence he left…
All encouraged her to: “forgo
further pursuit”; “he is likely deceased
by now”—his vessel (what left) scuttled amidst
the rocks of Cape Horn, yet Zara could feel
deep-seated inside her soul he is alive;
Alive (somewhere) fighting to return home.
Never would Zara leave; never would she
abandon post; she made that promise five
years ago as Abraham, ‘n’ his crew,
set out on their final voyage; and she (100)
would be ****** ere she broke her promise—a promise
of the heart—a promise of love. Abraham
said: “You are my lighthouse; your love, it, will guide
me home—keep me from danger—as long as you
remain my lighthouse, I’ll forever be
set to return home—return home to you.”
Out from Crosshaven did the old man take
steadfast Abraham en route to his home.
Grey Irish skies turned blue as they made their
way out on the Irish Sea, southwest, toward (110)
the southern end of the Appalachian Island.
The gentle biting spray of the waves breaking
over the bow and beam moistened the ginger
bearded face of Abraham; his tattooed
hands grasped the helm—his resolute stare kept him
and the old man acutely on course.
A shame,
it struck the old man, this would be the final
voyage of Abraham… he: the best crew
that the old man had ever came across; (120)
uncertain if simply the character
of Abraham or his pers’nal desire
to return home in the wake of five long
salty-cold years—a vassal to the Sea
and her changing whim. Never had the old
man seen his ship sail as fast as he did when
Abraham accorded its deck—each sail
set without flaw: easing and trimming sheets
fractions of an inch—purely to obtain
the slightest gain in speed; the display warmed (130)
the heart of the old man.
And thus the elder
gent mused as he lightly puffed on his pipe
while sitting on the stern pulpit regarding
at Abraham’s passion to return home
(as he calls her):—maybe dis is d’ reason
d’ Sea has fought so hard, and lied, t’ keep
Abraham from returning home… Could not
bear t’ lose such fine a sailor from her
expanses—she is known t’ be quite a jealous (140)
mistress…
But for all Abraham’s will and passion,
the old man insisted for the fellow
to rest; otherwise lack of sleep would cause
the REM fiddler to reap his debt—replace
clarity of mind with opacity.
Reluctantly stalwart Abraham gave
in and retire below deck—yet the old
man doubted the amount of rest that he
acquired in those moments out of his sight. (150)
For the days, then weeks, in the wake of their
departure from the port-island Crosshaven,
the seas were calm as open water can:
gentle azure rolling swells oscillated
and helped impel the vessel forward. The southern
craggy cape of the Appalachian
Island pierced the horizon. Like a threshold
it stood for Abraham—a major landmark;
the closest to home he had been in five
salty long years—his limbo was beginning (160)
to fade, his heart slowly—for the first time since
he left port in eastern Colorado—
started to feel replete again. The Great
Plains Sea—his final sea—he would not miss
the gleam of his lighthouse stalwart on shore.
Book Two
Oracle:**
Upon a beach, Abraham found himself alone—gasping
in gulps of moist air like that of a new born baby first (10)
experiencing the breathe of life; he felt as if he
would never become dry again… the salt burning his skin
as it crusted over when the water evap’rated
into the air; Abraham took the first night to rest, the
next day he set to make shelter and wait for a rescue
crew; out he stared at the crashing waves hoping for a plane
or faint form of a ship upon the horizon…days and
nights spun into an alternating display of day then
night: light then dark—light, dark, light, dark, grey, grey, grey…
Abraham (20)
gave up marking the days—realized the searches are done—
given up after looking in the wrong places (even
he did not know where he was…) the cold waves and currents took
him to a safe shore away from his ship and crew, in a
limp unconscious float…
From the trees, and what he could find on
the small island, Abraham occupied himself with the
task of building a catamaran to rid himself of
the grey-waiting.
Out he cast his meager vessel into (30)
the battering surf; waves broke over his bows and centre
platform—each foot forward, the waves threatened to push him back
twofold… Abraham struck-beat the water with the oars he
fashioned; rising and falling with the energy of the
waves; Abraham stole brief looks back with hopes of a van’shing
shoreline—coast refused to vanish… his drenched arms grew tired;
yet he pushed on knowing he would soon be out passed the
breaking waves; then could relax and hoist sail; yet the waves grew
taller—broke with greater power… Abraham struck-beat the
water with his oars—anger welled—leading to splashes of (40)
ivory sea-froth instead of the desired progress
forward; eventually, his arms fell limp beyond the
force of will… waves tumbled him back to shore as he did the
first night upon the island…
Dejected Abraham lay
in the surf that night—the gentle ebb of the sea added
to insult, but hid the tears formed in the corner of his eyes—
salt water to salt water… the next day Abraham took
inventory of damage: the mast snapped in multiple
places, the rudders askew—the hulls and centre structure (50)
remained intact; the oars lost (or at least Abraham cared
not to search); over the next weeks he set to improve
the design and efficiency of his vessel—the first
had been hurried and that of a man desperate to leave;
the bare minimum that would suffice—he set to create
a vessel to ensure his departure from the des’late
accrue of sand and vegetation; Abraham laboured
to strengthen his body—pushing his arms further passed the
point his mind believed they could go—consuming the hearty,
protein-rich, mollusks, and small shellfish he could find inside (60)
tide pools or shallows—if lucky, larger fish that dared the
nearby reefs.
Patiently, Abraham observed the tides and
breaking water; he wanted to determine the correct
time to set off to ensure success—when the waves would not
toss him back to the beach; the day: a calm clear day—only
within few metres of soft beach did there exist any
breaking waves, and those that broke were barely a metre high;
loading provisions upon the vessel, Abraham bid
farewell to the island (out of wont for the sustenance (70)
it gave not for nostalgia) grasping his oars, he set forth
to find open sea—where the waves do not break and set you
gingerly on foreign shore(s); Abraham paddled passed the
first few breaking waves, his heart pounding with hope—he stifled
the thoughts (celebrate when the island is but a subtle
blue curve upon the horizon); as the island began
to shrink in his vision, the sky to his back grew darker…
the waves started to swell—moguls grew to hills—Abraham
stroked up and rode down; the cursèd Island refused to shrink…
if not begin to grow wider… stroke by stroke Abraham (80)
grew frustrated—stroke by stroke frustration advanced into
anger—stroke by stroke anger augmented into fiery
beating of the water!—Abraham struck and struck at the
Sea—eyes closed—white knuckles—trashing!—unsure which direction
he paddled…sky pitch-black, wind blowing on-shore Abraham
bellowed out to the Sea in inarticulate roars of:
hatefrustrationpitydesperationheartache!
Towards
Abraham’s in-linguistic roar, the sky let out a crack
of authority! a wave swept the flailing Abraham (90)
into the ocean—cool water only heated the rage
in Abraham’s mind—his half empty heart only wanted:
to sail home, become whole again—sit under and olive
tree and stroke the chestnut hair of Zara as she drifted
off to sleep on his chest while he would whisper sweet verses
into her ear… Abraham’s rage, beyond reason, forgot
the boat and all clarity, he tried to swim away from
the cursèd island—scrambling up waves only to tumble
back with their breaking peaks—salt, the only taste in his mouth;
churning his stomach to *****; his kidney’s praying he (100)
would not swallow anymore… his gasps stifled any curse
Abraham’s head wished to expel onto the Sea—yet she
swore she heard one final curse escape his lips! at that the
Sea tossed Abraham (head first) into his ghost-helmed vessel—
all went dark for hostile Abraham…
Contemplating back
at his rage—knowing the barbarian it makes of him,
Abraham peered into the band inscribed into his
ring-finger and saw the knot tying him to Zara—shame
at his arrogant-uncontrolled-fury sent Abraham (110)
into a meditative exile inside of his mind
(within the exile of the island…) in his mental
exile Abraham spun into deeper despair at his
two failures—even more at the prospect of failing the
vow he professed onto Zara: return home—home from this
final voyage, grow old with her on solid ground, never
to die apart and cause the pain of losing a loved one
without the closure of truly knowing the death is real,
to die by her side white, white with the purity of age…
Abraham’s destitution turned inward—his fury, the (120)
lack of control, the demon he becomes when rage surges
through his muscles; equiping him with untamed strength without
direction or self-possession—so much potential, yet
no productive way to use it… Abraham’s half-full-heart
burned, ached with passion and anguish—all desire
focused on home, his return, but the mind’s despondency
and insistent ‘what-ifs’ kept poor Abraham prostrate in
his mental cave—all his wishing for anger and vi’lence
to force his will, it did more to retain him upon the
cursèd island than bring his heart closer to fulfillment: (130)
his long awaited home…
Out of his mental exile did
Abraham’s irises dilate and contract with blinding
illumination—self-pity is not what make things happen—
it would only serve to anger Zara—nothing other
than I can be to blame for my continued absence; I
am stronger than that!—looking at the tattoo in his hand,
he remembered the reasons for the perennial brand—
the eight-spoke ship’s helm: the eight-fold-path—I must cut off my
desire for anger to be the solution and focus (140)
on the one path to Zara—the mind can push the body
further than the body believes is possible—the star:
the compass to guide me via celestial bodies
to where my heart can see the guiding beam of my lighthouse!
Prelude:
As Romans before them, they built the city upward—
layer ‘pon layer as the polar caps receded
layer by layer—preserving what they could, if someday
the waters may recede back into the former polar
ice caps; restoring the long inundated coastlines.
Home:
A man sat upon a tall pub stool stroking
his ginger beard while grasping a pint loosely
in his other hand. An elderly gent stood
next to him. The older gentleman noticed
that the ginger bearded man’s pint sat almost
quite near the bottom of its tulip glass.
A woman with eyes of amber and hair
as chestnut strolled through a vineyard amongst
the ripening grapes full of juice to soon
become wine. She clutched a notebook—behind (10)
thick black covers lay ideas and sketches
to bring the world to a more natural
state—balancing the wonders and the merits
of technology apace with the allure ‘n’
sanctity borne to the natural world.
When the ginger bearded man finished the
final drops of his stout, another appeared
heretofore him—courtesy owed to the elder
gentleman. “Notice dat ye got d’ mark
o’ a man accustom amid the seas,” (20)
he inferred; gesturing the black and blue
compass rose inscribed inside a ship’s wheel,
imbedded into the back of the ginger
bearded man’s weathered right hand.
“I have crewed
and skippered a many fine vessel, but I
am renouncing my life at sea—one final
voyage I have left inside of me:
one single terminal Irish-Atlantic
voyage t’ward home.” (30)
“Aye d’ sea can beh cold
‘nd harsh, but she enchants me heart. Ta where
are ye headed fer d’ place ye call home,
d’ere sonny boy?”
“’tis not simply a where,
‘tis a who. Certain events have led me
to be separate from my wife. For five
eternal years I have been traveling—
waiting to be in her embrace. The force
of the Sea, she, is a cruel one. For (40)
it seams: at every tack or gybe the farther
off I am thrown from my homeward direction
to stranger and stranger lands… I have gone
to the graveyard of hell and the pearly gates
of (the so called) heaven; I have engaged
in foolhardy deals—made bets only a
gambling addict would place. All to just be
with Zara. I am homesick—Zara is my
home—it doesn’t matter where (physically)
we are located, my home is with Zara. I (50)
was advised to draw nigh the clove of Cork
and wait; wait for a man, but I was barely
given a clue as to who this man is,
only I must return him this:” the ginger
bearded man held out a dull silver pocket watch
with a frigate cut into the front cover
and two roses sharing a single stem
swirling upon themselves cut into
the back.
“Can it be? ‘Tis meh watch dat meh (60)
fat’er gave t’ meh right before he died…
I lost it at sea many a year ago.
It left meh heartbroken—fer it was meh only
lasting mem’ry of him… Come to t’ink I
was told by a beggar in the street—I
do not remember how long ago—dat
I would happen across a man wit’ somet’ing
dear t’ meh, and I’d accomp’ny dis man
on a journey, and dis man would have upon
‘im d’ mark of a true sailor…” (70)
“Dear elder man,
my name is Abraham; the mark you see
represents the control that I have on my
direction—thought it appears the Sea retains
some ascendancy… Yet now, it appears,
the Sea is upholding her bargain—though
a bit late... Do you, by chance, own a vessel
that can fair to Colorado?—all across
this mist’d island no skipper ‘ll uptake
my plea; they fear the sharp wrath of the Sea (80)
or (if they have no fear) simply claim my home
‘is not on their routes…’ i’tis a line I’ve
heard too often. I would’ve purchased a vessel,
but the Sea, she, has deprived me completely
of my identity and equity.”
Zara, with her rich chestnut hair sat upon
a fountain in a piazza—her half empty
heart longing to savor the hallow presence
of Abraham, and stroke his ginger beard…
Everyday she would look out at the sea (90)
whence he left…
All encouraged her to: “forgo
further pursuit”; “he is likely deceased
by now”—his vessel (what left) scuttled amidst
the rocks of Cape Horn, yet Zara could feel
deep-seated inside her soul he is alive;
Alive (somewhere) fighting to return home.
Never would Zara leave; never would she
abandon post; she made that promise five
years ago as Abraham, ‘n’ his crew,
set out on their final voyage; and she (100)
would be ****** ere she broke her promise—a promise
of the heart—a promise of love. Abraham
said: “You are my lighthouse; your love, it, will guide
me home—keep me from danger—as long as you
remain my lighthouse, I’ll forever be
set to return home—return home to you.”
Out from Crosshaven did the old man take
steadfast Abraham en route to his home.
Grey Irish skies turned blue as they made their
way out on the Irish Sea, southwest, toward (110)
the southern end of the Appalachian Island.
The gentle biting spray of the waves breaking
over the bow and beam moistened the ginger
bearded face of Abraham; his tattooed
hands grasped the helm—his resolute stare kept him
and the old man acutely on course.
A shame,
it struck the old man, this would be the final
voyage of Abraham… he: the best crew
that the old man had ever came across; (120)
uncertain if simply the character
of Abraham or his pers’nal desire
to return home in the wake of five long
salty-cold years—a vassal to the Sea
and her changing whim. Never had the old
man seen his ship sail as fast as he did when
Abraham accorded its deck—each sail
set without flaw: easing and trimming sheets
fractions of an inch—purely to obtain
the slightest gain in speed; the display warmed (130)
the heart of the old man.
And thus the elder
gent mused as he lightly puffed on his pipe
while sitting on the stern pulpit regarding
at Abraham’s passion to return home
(as he calls her):—maybe dis is d’ reason
d’ Sea has fought so hard, and lied, t’ keep
Abraham from returning home… Could not
bear t’ lose such fine a sailor from her
expanses—she is known t’ be quite a jealous (140)
mistress…
But for all Abraham’s will and passion,
the old man insisted for the fellow
to rest; otherwise lack of sleep would cause
the REM fiddler to reap his debt—replace
clarity of mind with opacity.
Reluctantly stalwart Abraham gave
in and retire below deck—yet the old
man doubted the amount of rest that he
acquired in those moments out of his sight. (150)
For the days, then weeks, in the wake of their
departure from the port-island Crosshaven,
the seas were calm as open water can:
gentle azure rolling swells oscillated
and helped impel the vessel forward. The southern
craggy cape of the Appalachian
Island pierced the horizon. Like a threshold
it stood for Abraham—a major landmark;
the closest to home he had been in five
salty long years—his limbo was beginning (160)
to fade, his heart slowly—for the first time since
he left port in eastern Colorado—
started to feel replete again. The Great
Plains Sea—his final sea—he would not miss
the gleam of his lighthouse stalwart on shore.
Book Two
Oracle:**
Upon a beach, Abraham found himself alone—gasping
in gulps of moist air like that of a new born baby first (10)
experiencing the breathe of life; he felt as if he
would never become dry again… the salt burning his skin
as it crusted over when the water evap’rated
into the air; Abraham took the first night to rest, the
next day he set to make shelter and wait for a rescue
crew; out he stared at the crashing waves hoping for a plane
or faint form of a ship upon the horizon…days and
nights spun into an alternating display of day then
night: light then dark—light, dark, light, dark, grey, grey, grey…
Abraham (20)
gave up marking the days—realized the searches are done—
given up after looking in the wrong places (even
he did not know where he was…) the cold waves and currents took
him to a safe shore away from his ship and crew, in a
limp unconscious float…
From the trees, and what he could find on
the small island, Abraham occupied himself with the
task of building a catamaran to rid himself of
the grey-waiting.
Out he cast his meager vessel into (30)
the battering surf; waves broke over his bows and centre
platform—each foot forward, the waves threatened to push him back
twofold… Abraham struck-beat the water with the oars he
fashioned; rising and falling with the energy of the
waves; Abraham stole brief looks back with hopes of a van’shing
shoreline—coast refused to vanish… his drenched arms grew tired;
yet he pushed on knowing he would soon be out passed the
breaking waves; then could relax and hoist sail; yet the waves grew
taller—broke with greater power… Abraham struck-beat the
water with his oars—anger welled—leading to splashes of (40)
ivory sea-froth instead of the desired progress
forward; eventually, his arms fell limp beyond the
force of will… waves tumbled him back to shore as he did the
first night upon the island…
Dejected Abraham lay
in the surf that night—the gentle ebb of the sea added
to insult, but hid the tears formed in the corner of his eyes—
salt water to salt water… the next day Abraham took
inventory of damage: the mast snapped in multiple
places, the rudders askew—the hulls and centre structure (50)
remained intact; the oars lost (or at least Abraham cared
not to search); over the next weeks he set to improve
the design and efficiency of his vessel—the first
had been hurried and that of a man desperate to leave;
the bare minimum that would suffice—he set to create
a vessel to ensure his departure from the des’late
accrue of sand and vegetation; Abraham laboured
to strengthen his body—pushing his arms further passed the
point his mind believed they could go—consuming the hearty,
protein-rich, mollusks, and small shellfish he could find inside (60)
tide pools or shallows—if lucky, larger fish that dared the
nearby reefs.
Patiently, Abraham observed the tides and
breaking water; he wanted to determine the correct
time to set off to ensure success—when the waves would not
toss him back to the beach; the day: a calm clear day—only
within few metres of soft beach did there exist any
breaking waves, and those that broke were barely a metre high;
loading provisions upon the vessel, Abraham bid
farewell to the island (out of wont for the sustenance (70)
it gave not for nostalgia) grasping his oars, he set forth
to find open sea—where the waves do not break and set you
gingerly on foreign shore(s); Abraham paddled passed the
first few breaking waves, his heart pounding with hope—he stifled
the thoughts (celebrate when the island is but a subtle
blue curve upon the horizon); as the island began
to shrink in his vision, the sky to his back grew darker…
the waves started to swell—moguls grew to hills—Abraham
stroked up and rode down; the cursèd Island refused to shrink…
if not begin to grow wider… stroke by stroke Abraham (80)
grew frustrated—stroke by stroke frustration advanced into
anger—stroke by stroke anger augmented into fiery
beating of the water!—Abraham struck and struck at the
Sea—eyes closed—white knuckles—trashing!—unsure which direction
he paddled…sky pitch-black, wind blowing on-shore Abraham
bellowed out to the Sea in inarticulate roars of:
hatefrustrationpitydesperationheartache!
Towards
Abraham’s in-linguistic roar, the sky let out a crack
of authority! a wave swept the flailing Abraham (90)
into the ocean—cool water only heated the rage
in Abraham’s mind—his half empty heart only wanted:
to sail home, become whole again—sit under and olive
tree and stroke the chestnut hair of Zara as she drifted
off to sleep on his chest while he would whisper sweet verses
into her ear… Abraham’s rage, beyond reason, forgot
the boat and all clarity, he tried to swim away from
the cursèd island—scrambling up waves only to tumble
back with their breaking peaks—salt, the only taste in his mouth;
churning his stomach to *****; his kidney’s praying he (100)
would not swallow anymore… his gasps stifled any curse
Abraham’s head wished to expel onto the Sea—yet she
swore she heard one final curse escape his lips! at that the
Sea tossed Abraham (head first) into his ghost-helmed vessel—
all went dark for hostile Abraham…
Contemplating back
at his rage—knowing the barbarian it makes of him,
Abraham peered into the band inscribed into his
ring-finger and saw the knot tying him to Zara—shame
at his arrogant-uncontrolled-fury sent Abraham (110)
into a meditative exile inside of his mind
(within the exile of the island…) in his mental
exile Abraham spun into deeper despair at his
two failures—even more at the prospect of failing the
vow he professed onto Zara: return home—home from this
final voyage, grow old with her on solid ground, never
to die apart and cause the pain of losing a loved one
without the closure of truly knowing the death is real,
to die by her side white, white with the purity of age…
Abraham’s destitution turned inward—his fury, the (120)
lack of control, the demon he becomes when rage surges
through his muscles; equiping him with untamed strength without
direction or self-possession—so much potential, yet
no productive way to use it… Abraham’s half-full-heart
burned, ached with passion and anguish—all desire
focused on home, his return, but the mind’s despondency
and insistent ‘what-ifs’ kept poor Abraham prostrate in
his mental cave—all his wishing for anger and vi’lence
to force his will, it did more to retain him upon the
cursèd island than bring his heart closer to fulfillment: (130)
his long awaited home…
Out of his mental exile did
Abraham’s irises dilate and contract with blinding
illumination—self-pity is not what make things happen—
it would only serve to anger Zara—nothing other
than I can be to blame for my continued absence; I
am stronger than that!—looking at the tattoo in his hand,
he remembered the reasons for the perennial brand—
the eight-spoke ship’s helm: the eight-fold-path—I must cut off my
desire for anger to be the solution and focus (140)
on the one path to Zara—the mind can push the body
further than the body believes is possible—the star:
the compass to guide me via celestial bodies
to where my heart can see the guiding beam of my lighthouse!
This is the Final Voyage epic thus far. I am converting Home into blank verse and it is taking longer than I thought to do; which is why that part is incomplete here. I also added line numbers. I changed The names as well.
Mydriasis Aletheia
Apr 2018
I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.
The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though not revealing it. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.
Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand Ki (nM) Ki (nM)
Target Flx Nflx
SERT 1 19
NET 660 2700
DAT 4180 420
5-HT2A 200 300
5-HT2B 5000 5100
5-HT2C 72.6 91.2
α1 3000 3900
M1 870 1200
M2 2700 4600
M3 1000 760
M4 2900 2600
M5 2700 2200
H1 3250 10000
Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site Ki (nM)
SERT 0.15–3.3
NET 420–925
DAT 22–315
5-HT1A >35,000
5-HT2A 2,207
5-HT2C 2,298
α1A 1900
α1B 3,500
α1D 2,500
α2 477–4,100
D2 10,700
H1 24,000
mACh 427–2,100
σ1 32–57
σ2 5,297
Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr Ki (nM)
SERT 2.5
NET 6,514
5-HT2C 2,531
α1 3,870
M1 1,242
H1 1,973
Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand, Vnfx Dvnfx
Recptr Ki(nM) Ki(nM)
SERT 82 40.2
NET 2480 558.4
Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site Ki (nM)
MOR 383–768 (Ki)
194 (EC50)
DOR >10,000 (Ki)
37,400 (EC50)
KOR >10,000 (Ki)
100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).
Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism. I took 150mg ******, as extended and as instant release (the latter was more pronounced). Interesting to compare with other cathinones, and curious to think of other bupropiologues (for example, 3-Methyl-N-tert-butyl-methcathinone). A decent compound, probably useful for a range of things beyond its indication.
Bupropion R,R-Hydroxybuprpn Threo-hydrobuprpn
AUC 1 23.8 11.2
Half-life 11 h 19 h 31 h
IC50 (μM)
DAT 0.66 inactive 47 (rat)
NET 1.85 9.9 16 (rat)
SERT inactive inactive 67 (rat)
α3β4 nic 1.8 6.5 14 (rat)
α4β2 nic 12 31 no data
α1β1γδ nic 7.9 7.6 no data
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), slight indications of serotonergicity later became apparent when in bed: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe and synergistic (perfect for pharmahuasca), but is very dangerous to combine with serotonergic drugs.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.
The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though not revealing it. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.
Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand Ki (nM) Ki (nM)
Target Flx Nflx
SERT 1 19
NET 660 2700
DAT 4180 420
5-HT2A 200 300
5-HT2B 5000 5100
5-HT2C 72.6 91.2
α1 3000 3900
M1 870 1200
M2 2700 4600
M3 1000 760
M4 2900 2600
M5 2700 2200
H1 3250 10000
Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site Ki (nM)
SERT 0.15–3.3
NET 420–925
DAT 22–315
5-HT1A >35,000
5-HT2A 2,207
5-HT2C 2,298
α1A 1900
α1B 3,500
α1D 2,500
α2 477–4,100
D2 10,700
H1 24,000
mACh 427–2,100
σ1 32–57
σ2 5,297
Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr Ki (nM)
SERT 2.5
NET 6,514
5-HT2C 2,531
α1 3,870
M1 1,242
H1 1,973
Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand, Vnfx Dvnfx
Recptr Ki(nM) Ki(nM)
SERT 82 40.2
NET 2480 558.4
Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site Ki (nM)
MOR 383–768 (Ki)
194 (EC50)
DOR >10,000 (Ki)
37,400 (EC50)
KOR >10,000 (Ki)
100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).
Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism. I took 150mg ******, as extended and as instant release (the latter was more pronounced). Interesting to compare with other cathinones, and curious to think of other bupropiologues (for example, 3-Methyl-N-tert-butyl-methcathinone). A decent compound, probably useful for a range of things beyond its indication.
Bupropion R,R-Hydroxybuprpn Threo-hydrobuprpn
AUC 1 23.8 11.2
Half-life 11 h 19 h 31 h
IC50 (μM)
DAT 0.66 inactive 47 (rat)
NET 1.85 9.9 16 (rat)
SERT inactive inactive 67 (rat)
α3β4 nic 1.8 6.5 14 (rat)
α4β2 nic 12 31 no data
α1β1γδ nic 7.9 7.6 no data
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), slight indications of serotonergicity later became apparent when in bed: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe and synergistic (perfect for pharmahuasca), but is very dangerous to combine with serotonergic drugs.