Recently I was misidentified as a psychonaut
so allow me to clarify,
I am not.

I am no longer
part of that cabal,
I am no more a psychonaut than I am a catholic;

But, as a philosopher, I will write of it.


Psychonautics is an act of configuration.
It refers to a methodology
for describing and explaining
configurations of consciousness,
And a research cabal
in which adherents explore
and harness those configurations.

The power of psychonautics
is that configurations of consciousness
have resonant effects on meaning and belief.
The psychonautic cabal emerges from a recognition of this.

Psychonautic exploration is not without risk
to the physical and psychological well-being
of the researcher, to their essence and beliefs.

An experienced and trustworthy practitioner
can provide a tether to your shared reality,
Advanced practices require caution and patience
to navigate safely; "[t]here is no casual experiment".


In the Western paradigm, classical psychonautics
was defined by contemplative and ritual techniques,
The religious or spiritual practices of a tribe or society.

Modern psychonautics has been increasingly defined by
the use of psychoactive substances, which is likely the result
of secularization, advances in pharmacy, and the war on drugs.

In contemporary society psychoactives are a valuable commodity
that many people use (or misuse) for a variety of reasons.

Some will seek out drugs they have not tried before,
Few shall devote themselves entirely, investing
their time and resources in learning about,
acquiring and assessing psychoactives.

This latter cohort aligns with the methodology
of psychonautics, they commit to understanding
through practice. Many become well-versed
in Novel Psychoactive Substances (NPS),
Some academics assume this is the mark of the modern psychonaut
but it is mere specialization  rather than characteristic thereof.


As more initiates into psychonautics emerge from drug experiences
so does the cabal become more chemical. Nevertheless
it draws its adherents from a diversity of practices.

Psychonautic practices entail ontological risks,
The ranks of the cabal are full
of disordered, misguided, or warped adherents
whose heedless practice undermines
the meaningfulness of consensual reality.
A lack of formal training and mental health
likely contribute to this, although no equation
can encapsulate the qualitative experience which
compromises ontological security.


The cabal is decentralized, without singularly defined leadership
or ideals, and it operates through intrigue. Its adherents
may dispute the ethos or validity of some practices
and their corresponding configurations, and so
within the cabal there is an internal politics:

Cognitive liberals
believe anyone using responsibly
should be allowed their methodology and be able to practice.

Universalists or absolutists
believe everyone should be initiated, if not adherent.

Elitists and psychocrats
hold that only their method and practice is valid.

Cognitive dissidents
believe the methodology and its praxis must not be vested
in nation-states, corporations, or religions
if it is/they are to retain its power.

The cabal's politics of intrigue
represent an unspoken power struggle
where the stakes are unclear, if even communicable.

If the war on drugs comes to an end, psychonautics
will be redefined by its next wave of initiates,
May they be wise and kind.


I have written enough,
That part of my life is well and truly over.
My purpose here is to explore ideas, to experiment with poetry.
The place I allocate psychoactives
has always been secondary to that;

Rarely do I deign to sail the soul now
but when I do, know I am a philosopher

and do so as an inquiry into mind
rather than in service of alteration.

Oh, to be Anonymous
in that sweet darkness.

Ah, to be Philalethes
in the pursuit of truth.

Joy, to be with Pasithea
enveloped by relaxation.

Sorrow, to be a **** Lord
that never to comes-down.

All observation is from a particular point, but
acknowledged subjectivity's better than naught.
Thus follows some comments on their qualitative nature.
Use them as you deem. In this piece everything is as it seems.

Caffeine is unappreciated enough,
Give credit to that stimulant for the things it does.
Coffee has little time to play, for there are errands
to attend to before the light fades.

The amphetamine will spin you until you're spun,
The cathinone will also try you with its luck.
The stimulant is a trickster [touch within]
and a magician never reveals their secret,
Even when seeking it befalls endlessness.

Me and E(cstasy) used to dance all night,
Closer to all your dreams was as far
from the light, we soaked ourselves
in emotionality and I soared high:
Perfection in the dark
rekindled my heart; 'cause
on pills you love everyone.

******* is always hungry but will never feed you
for it is naught but the scent of pure ego;
because on coke everyone loves you.

There is nothing to learn from an opioid or benzodiazepine
beyond the hedonistic stupor in-between awake and sleeping.
Similarly, cigarettes never taught me anything about myself
much like quick, ***** ***, that's nicotine and painkillers, in essence.

Alcohol is reliable for those sociable
but can hurt the body and scorn the emotional.
Drink toyed with me, then she abandoned me;
Despite that messiness I still reminisce occasionally.

Gamma-HydroxyButyric acid [GHB] requires utmost caution,
One must observe the proper conduct when
wading through such subtle intoxication.

Don't use ket too much, don't use angel dust.
If you want a supreme arylcyclohexylamine
seek out methoxetamine, use it responsibly.
Dissociation, end of line; no[thing is o]ne.

Always be considerate before transcending reality,
Reverence for psychedelics keeps them self-regulatory.
Of all the compounds they would humble and reveal to you;
Existential, being when tripping; every[is]one.

Cannabis I dared to use recreationally
for it often reminded us when one should act sensibly.
That deep conversing with trusted friends
is better than any substance I have ever had the nerve to test.

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.