I've been acquainted with the following
psychoactives compounds:

Depressants & Dissociatives;
Ethanol / EtOH / alcohol, drink, *****
γ-Hydroxybutyric acid / GHB / G, fantasy
β-Phenyl-γ-aminobutyric acid / PhGABA / Phenibut
Dextromethorphan / DXM / Benylin, Robitussin
Morphine / Papaver somniferum / *****
3-Methylmorphine / Codeine
Dihydrocodeine / DHC
Buprenorphine / Subutex, Suboxone
N-Allylnoroxymorphone / Naloxone / Suboxone, Narcan
Tramadol / Ultram
O-Desmethyltramadol/ O-DSMT / Omnitram
Thiopental / Sodium Pentothal
Diazepam / ******
2'-Chlorodiazepam / Ro5-3448 / Diclazepam
4'-Chlorodiazepam / Ro5-4864
Chlordiazepoxide / Librium
Gidazepam, hidazepam
Desalkylgidazepam / Bromonordiazepam
N-Desalkylfluarazepam / Norfluarazepam
Flubromazepam
Alprazolam / Xanax
Bromazolam / XLI-268
Clonazolam, Clonitrazolam / Clam
Etizolam / Etilaam, Etizest
Flualprazolam
Flubromazolam
Zopiclone / Zimovane
Pagoclone
Promethazine / Phenergan
Diphenhydramine / DPH / Benadryl, Nytol
Chlorphenamine, chlorpheniramine / CPM / Piriton
Cetirizine / Zyrtec
Amitriptyline / Elavil
Tianeptine / Coaxil, Stablon
Mirtazapine / Remeron
Quetiapine / Seroquel
Nitrous Oxide / N2O / laughing gas
Amyl Nitrite / Poppers
Ketamine [racemic] / K, Kitty
Esketamine [S-isomer] / Special K
Deschloroketamine / 2'-Oxo-PCM / DCK
N-ethyldeschloroketamine / 2'-Oxo-PCE / O-PCE / Eticyclidone
Deoxymethoxetamine / 3-Me-2′-Oxo-PCE / DMXE
Methoxetamine / 3-MeO-2'-Oxo-PCE / MXE / Mexxy
Hydroxetamine / 3-**-2'-Oxo-PCE / HXE / Hexxy
Methoxpropamine / 2-Oxo-3'-MeO-PCPr / MXPr
Methoxisopropamine / 2-Oxo-3'-MeO-PCiPr / MXiPr
3-Hydroxyphencyclidine / 3-**-***
3-Methoxyphencyclidine / 3-MeO-***
3-Methoxyeticyclidine / 3-MeO-PCE
3-Methyleticyclidine / 3-Me-PCE

Stimulants & Enhancers;
1,3,7-Trimethylxanthine / Caffeine / Coffea, Camellia sinensis / Coffee, Tea
3,7-dimethylxanthine / Theobromine / [constituent of] Chocolate
N-Ethyl-L-glutamine / L-Theanine / [constituent of] Green Tea
Nicotine / Nicotiana / Tobacco, cigarettes, smokes
Ephedrine / Ephedra
Pseudoephedrine / Ephedra, Sudafed
Adrenaline, Epinephrine
Choline bitartrate
L-alpha glycerylphosphorylcholine / Alpha-GPC, Choline alfoscerate
Cytidine 5'-diphosphocholine / CDP-choline, Citicoline
N-Acetylcysteine / NAC
2-Dimethylaminoethyl (4-chlorophenoxy)acetate / Meclofenoxate
N-Phenylacetyl-L-prolylglycine ethyl ester / Omberacetam / Noopept
Coluracetam / BCI-540
4-Phenylpiracetam
Propranolol
(±)-2-Benzhydrylsulfinyleth­anehydroxamic acid / Adrafinil
(±)-2-[(Diphenylmethyl)sulfinyl]acetamide / Modafinil
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide / Armodafinil
α-Methylphenethylamine / Amphetamine, αMP / Speed
N-Methylamphetamine / Methamphetamine / ****
Lisdexamfetamine / Vyvanse, Tyvense, Elvanse
2-Fluoromethamphetamine / 2-FMA
3-Fluoroamphetamine / 3-FA /  PAL-353
4-Fluoroamphetamine / 4-FA, 4-FMP /  PAL-303 / Flux
4-Methoxyamphetamine / PMA, 4-MA / Death
5-Methoxy-2-aminoindane / MEAI, 5-MeO-AI / Chaperone, Pace
Methythiolpropamine / MPA / Blow
3-Fluorophenmetrazine / 3-FPM / PAL-593
Methylphenidate / MPH / Ritalin, Concerta
4-Fluoromethylphenidate / 4F-MPH
4-Fluoroethylphenidate / 4F-EPH
3-Methylmethcathinone / 3-MMC / Metaphedrone
3-Methylethcathinone / 3-MEC
4-Methylmethcathinone / 4-MMC / Mephedrone
4-Methylethcathinone / 4-MEC
3-Chloro-N-tert-butyl-cathinone / Bupropion / Wellbutrin, Zyban
4-Chloromethcathinone / 4-CMC / Clephedrone
4-Fluoromethcathinone / 4-FMC / Flephedrone
4-Fluoro-α-methylaminovalerophenone / 4-Fluoropentedrone / 4-FPD
α-Ethylaminocaprophenone / N-Ethylhexedrone / NEH / Hexen
alpha-Pyrrolidinohexiophenone / α-PHP / PV-7
alpha-Pyrrolidinoisohexaphenone / α-PiHP, α-PHiP
3,4-Methylenedioxy-α-pyrrolidinohexiophenone / MDPHP
3,4-Methyl​enedioxy​pentedrone / βk-MBDP / Pentylone
3,4-Methylenedioxymethcathinone / βk-MDMA / MDMC / Methylone
3,4-Methylenedioxymethamphetamine / MDMA / ecstasy
5-(2-methylaminopropyl)benzofuran / 5-MAPB
6-(2-Aminopropyl)benzofuran / 6-APB / Benzofury
6-(2-Aminopropyl)-2,3-dihydrobenzofuran / 6-APDB / 4-desoxy-MDA
Mesembrine / Sceletium tortuosum, Kanna
Harmine / Peganum harmala / Syrian Rue
3,4,8-Trimethoxyphenanthrene-2,5-diol / Dendrobium nobile
NSI-189
4-chloro-N-(2-morpholin-4-ylethyl)benzamide / Moclobemide
Escitalopram / Cipralex, Lexapro
Fluoxetine / Prozac
Sertraline / Zoloft
Venlafaxine / Effexor
5-Hydroxytryptophan / 5-HTP / Oxitryptan

Hallucinogens & Psychedelics;
Cannabidiol / CBD / Cannabis
Cannabigerol / CBG / Cannabis
Δ9-Tetrahydrocannabinol / THC / Cannabis, Marijuana
Hexahydrocannabinol / HHC
AM-2201 / Synth-'noids, Spice
NM-2201 / CBL-2201
5C-AB-PINICA
Salvinorin A  / Salvia Divinorum / Diviner's Sage
d-Lysergic acid amide / d-Lysergamide / LSA / Ergine
Lysergic acid diethylamide / Lysergide / LSD, LAD / Acid, Lucy
Lysergic acid 2,4-dimethylazetidide / LSZ / Diazedine, Lambda, λ
1-Acetyl-lysergic acid diethylamide / 1A-LSD / ALD-52
1-Propionyl-lysergic acid diethylamide / 1P-LSD
1-Cyclopropionyl-N-Methyl-N-isopropyllysergamide / 1cP-MiPLA
6-Allyl-6-nor-lysergic acid diethylamide / AL-LAD / Aladdin
2,5-Dimethoxy-4-methylamphetamine / DOM / Dominic
2,5-Dimethoxy-4-bromoamphetamine / DOB / Aphrodite
2,5-Dimethoxy-4-chloroamphetamine / DOC / Doctor
2,5-Dimethoxy-4-methylthioamphetamine / DOT / Aleph
2,5-Dimethoxy-4-methyl-α-ethylphenethylamine / 4C-D / Ariadne
2,5-Dimethoxy-4-methylphenethylamine / 2C-D, 2C-M / Matrix
2,5-Dimethoxy-4-ethylphenethylamine / 2C-E / Eternity
2,5-Dimethoxy-4-bromophenethylamine / 2C-B / Nexus
2,5-Dimethoxy-4-chlorophenethylamine / 2C-C / Callisto
2,5-Dimethoxy-4-iodophenethylamine / 2C-I / Infinity
2,5-Dimethoxy-4-methylthiophenethylamine / 2C-T / Tesseract
2,5-Dimethoxy-4-ethylthiophenethylamine / 2C-T-2 / Rosy
2,5-Dimethoxy-4-fluoroethylthiophenethylamine / 2C-T-21 / Aurora
2,5-Dimethoxy-4-bromo-β-keto-phenethylamine / βk-2C-B
2,5-Dimethoxy-4-bromo-β-hydroxy-phenethylamine / βOH-2C-B / BOHB
2,3,6,7-Benzo-dihydro-difuran-8-bromo-ethylamine / 2C-B-FLY
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-bromophenethylamine / 25B
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-chlorophenethylamine / 25C
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-iodophenethylamine / 25I
2,5-Dimethoxy-N-(2-hydroxybenzyl)-4-ethylphenethylamine / 25E-NBOH
3,4-Methylenedioxyamphetamine / MDA / Sass, Sally
3,4,5-Trimethoxyphenethylamine / Mescaline / M
3,5-Dimethoxy-4-ethoxyphenethylamine / Escaline
3,5-Dimethoxy-4-methallyloxyphenethylamine / Methallylescaline / MAL
α-Methyltryptamine / αMT / Indopan
N,N-dimethyltryptamine / DMT / The Spirit
N,N-dipropyltryptamine / DPT / The Light
N,N-Diisopropyltryptamine / DiPT / The Sound
N-Methyl-N-ethyltryptamine / MET / The Colour
N-Methyl-N-propyltryptamine / MPT
N-Ethyl-N-propyltryptamine / EPT
N-Methyl-N-isopropyltryptamine / MiPT / The Touch
4-Hydroxy-dimethyltryptamine / 4-**-DMT / Psilocybe / Psilocin
4-Phosphoryloxy-N,N-dimethyltryptamine / 4-PO-DMT / Psilocybin
4-Acetoxy-dimethyltryptamine / 4-AcO-DMT / Psilacetin
4-Hydroxy-N-methyl-N-ethyltryptamine / 4-**-MET / Metocin
4-Acetoxy-N-methyl-N-ethyltryptamine / 4-AcO-MET / Metacetin
4-Acetyloxy-N,N-dipropyltryptamine / 4-AcO-DPT / Pracetin
4-Acetoxy-N-methyl-N-cyclopropyltryptmine / 4-AcO-McPT
4-Acetoxy-N-methyl-N-isopropyltryptamine / 4-AcO-MiPT / Mipracetin
4-Hydroxy-N-methyl-N-isopropyltryptamine / 4-**-MiPT / Miprocin
5-Methoxy-N,N-dimethyltryptamine / 5-MeO-DMT / The God, The Power
5-Methoxy-N-methethyltryptamine / 5-MeO-MET / The Vision
5-Methoxy-N,N-diallyltryptamine / 5-MeO-DALT / Foxtrot
5-Methoxy-N-diisopropyltryptamine / 5-MeO-DiPT / Foxy
5-Methoxy-N-methyl-N-isopropyltryptamine / 5-MeO-MiPT / Moxy

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

day of the big extraction.
lower left molar
tooth number 18.
interesting chakra, that one.
sometimes a physical removal of energy is needed
to let the nadis breathe.
I got a double hernia repaired about a year ago.
anesthesia administered by St. Michael the Divine.
a whole granthi must have broken loose
while I was underneath the knife.
energetic knots all in a tangle in the sacral
burst into a cloud of scarabs and sanskaras
like a flock of a thousand white doves released
at a Louisiana Jazz Funeral.

the first time I sank into samadhi was late February 2021.
I was sitting in the lobby at Horizon Dental
third floor of the Guild building,  Wyoming avenue, Scranton, PA.
I was sipping coffee I got from the 1st floor
from the
Heaven and Earth Cafe
when my -
eyes rolled up into my skull
when my -
heart  buckled under the beauty
when my -
brain found its new home in a vat of warm static.
I felt like the Benedictine on the cross I got
from the christian trinket shop attached to the new cafe downstairs.
holy holy holy. glory be to god

this tooth has been giving me agita for two years
ever since the medicine
and the accident
and the hospital.
ever since I broke the Causal Egg.
novicaned
root canalled
capped with a cracked temporary
and now just a fractured stub of calcium
with three roots instead of two.

It only took a couple skillful shots to the face
before I couldn’t feel a thing.
except for twenty five minutes
of drilling
and cracking
and prying
and extracting the one thing that kept me grounded
when I was sitting in the common area of the 6th floor
of the CMC, Hill Section, Scranton, PA.

©️  Jordan Gee