๐๐๐ Drugs for the short term. B3 for life. ๐ Supplement with flush-free niacin (vit. B3), 500 m.g. with each meal. Melancholia is symptomatic of deficits in vitamins B1 & B3. Research Abram Hoffer (the late M.D., bio-chemist & co-creator of Orthomolecular medicine).