Depression/schizophrenia manifests itself in many ways. It's caused by a fatigued thalamus (the brain's switchboard). The thalamus controls sleep/wake cycles. A chronic insomniac's thalamus (in a self-preserving move) will mistakenly put a wakeful person into a sleep (dream) state. Schizoids are merely acting out dreams. The dreams to them are real. The natural medicine, that you mentioned, contained niacin (B3). The F.D.A. has been spiking wheat flour with niacin (vitamin B3) since 1938 to end the epidemic of the fatal B3-deficit disease pellagra. Pellagra carries psychosis, food aversion, insomnia as clinical symptoms. I suspect, but I can't prove, that the program (to vitalize the flour with niacin) has been curtailed, given that depression is epidemical in the West. The theory is viable that schizophrenia & anorexia nervosa are sub-clinical symptoms of the fatal niacin-deficiency disease known as pellagra. Either way, all B vitamins are water-soluble with no known toxicity. Take B3.