The Non-Interference Principle states: One should refrain from interfering with the personal choice to consume or reject a substance.
The Prime Directive states: One should advocate for spiritual development, one cannot advocate for that which they have no prior experience with or adequate knowledge of.
Both statements are applicable/in reference to all compounds which pass the blood-brain barrier, including but not limited to psychoactives/psychotropics. Only exceptional medical circumstances provide any grounds for exemption from these statements.