I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though  not reveal. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism and to what extent ROAs alter pharmacokinetics.
I took 150mg ******, as extended and as instant release (the latter was more pronounced). I thought an altered pharmakinetic profile might result from bypass of hepatic metabolism, so I tried 25mg insufflated and felt as if there was effect that it differed slightly from oral ROAs, but also worried that its metabolic fate is thence unknown (compare to the neurotoxic 3-CMC). What of other bupropiologues,
for example, 3-Methyl-N-tert-butyl-methcathinone? Indeed.
                        Bupropion    R,R-Hydroxybuprpn   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), indications of serotonergicity later became apparent: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A stark reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe, and synergistic (perfect for pharmahuasca); reputed to potentiate GHB. However, generally it is extremely dangerous to combine with serotonergic drugs.

Grand mamma always told me
Hold your head up proud
And never accept to blend in with the crowd-
Kinna strange the way
I'm parting rivers right now
And how if sitting silent
I'm truly speaking out loud

Long ago and swiftly
Juggling dozens of eggs
Though trying not to split 'em
I tripped up on some pegs
The yoke leaked out
Mixed with the blood
From my head
I didn't whimper yet I knew
My beauty was dead-
But that's how it grows
All you Elaine's and Ed's
Through brazen heat
And tempest sleet
Chewing on led

While inspires cry
And empires fry
That sandstone shifts
And driftwood drifts
Alone I merrily roam
With my for sure's and if's
Never dissuading
The hemispheres
Of my bliss

Ah, Pinocchio--povero burattino°--
Always in a scrape; always in a jam.
The irresponsible, wooden-headed numbskull
Couldn't help but fall for every scam.
 
A walking, talking stringless marionette,
Pinocchio really would have had it made
In a modest home with babbo°° Gepetto.
But, instead, the foolish youngster strayed.
 
Ignoring the advice of the talking cricket,
Pinocchio EVEN smashed it with a hammer.
That right there should have been a reason
To throw the little rascal in the slammer.
 
The Fox and the Cat had no trouble
Dissuading the puppet from going to school,
Thus involving him in a series of adventures
Which often made him look like a fool.
 
The Fairy tried to be a good influence,
But Pinocchio's lies caused his nose to grow.
Constantly ignoring responsibilities,
The misguided boy, suffered constant woe.
 
(Swindled of his money, hanged on a tree,
And saved just in the nick of time
From being eaten, Pinocchio had
Too many adventures to fit into this rhyme.)
 
Fleeing with his lazy school chum Lucignolo
To the Paese dei balocchi,°°° there Pinocc
Turned into a donkey. Of all his follies,
This one had to be a masterstroke.
 
Once again a puppet, Pinocchio was swallowed
By a giant Pesce-cane,°°°° and then guess what!
The foolish boy was finally reunited
With babbo Gepetto in the fish's huge gut.
 
NOT until Pinocchio thought about others
And proved he was an honest and caring boy
Did his fortune start to change for the better,
And the stringless puppet became the real McCoy.
 
Does Pinocchio by any chance remind you
Of any politicians out there at all
Who fail to listen to expert advice
And thumb their noses at common protocol?
 
And speaking of noses, we can also see
Politicians' noses grow as they tell lies.
Lying to themselves and to others as well
And ignoring our best interests and flouting compromise.
 
Such politicians--unlike Pinocchio--
Have strings to pull when performing for the masses.
The more they avoid solving REAL issues,
The more they end up looking like *****.
 
They also love--these clever burattini--
To sell a bill of goods and promise many things.
But someone out there--or some corporation--
Is slyly and cleverly pulling their strings.
 
Do you ever wonder if these same politicians
Ever think about or care how you feel?
Will they eventually--as did Pinocchio--
Prove they have what it takes to be real?
 
 
°(burattino/i) - poor little puppet
°°(babbo) - dad(dy)
°°°(Paese dei balocchi) - Playland
°°°°(Pesce-cane) - shark

- by Bob B

The universe is an infinite structure.
Our lives however, are not.
Life must end because with no end, there is no beginning.
Humanity is programmed to fear death.
Haven't you realized that we are born to die?
Please, don't perceive this notion as negative or dissuading.
Death allows us to return to our innocence,
Only to be limitlessly reborn in a higher form.
When we die, we are not gone,
Rather we are no longer a single whole.
Every molecule that was in us will be present in multiple forms of life.
It isn't the end of a journey,
Rather the start of a beautiful endeavor.

scribbled heartbeats hidden in pages
breath pulsing against the cheek
a heart that thumps beneath fingertips
grass blades breaking under the weight of two bodies stacked
and mouths smacked together

time is irrelevant
the rest are just ghosts
& the world
will slide into shadow with the bright of conjoined lives

the romantics have been pushed to sea
the ***** in our skulls dissuading the heart from leaping
where did the skeptics slink from?
slide back into your passionless tomb

this life is a heartbeat long
and it’s being wasted
on pebbles painted yellow
weigh down your pockets and when you find True Gold
hope that you have the courage to slice open the sleeves
and let the fools tumble out

the aching brilliance of the universes cruel joke
that fear that keeps us from leaping in fully
its a sad slide into lonely suicide
when you find the golden one
hold on and let the Love destroy what you were
and blossom you into what never dies

In the field where the stars turn into roses
come, take a risk
that is no risk
for Love like this is an embrace
that will never end.

Lions of worth
Sheer actual and letting a moon...
Save this last dance for danger
Creation and beckoning silence, come too soon

Throne of sense, a dissuading knot
Persuaded to live in the opus, the chastity
Of courtesy's phantom, a wisdom caught
A wisdom capable of the roses of vanity...

Vantage one (soliloquy)
Threats of privilege, share the land
Sour or dour, the notion to quell, is heed
Stricken with the mores of wishes, the tongue to wonder

Vantage two (espousal)
Worlds of visit, vicinity, and vagueness
Together for a question, in the form of wealth
We see your tomorrow, for today in a mirrors bless...

Vantage three (fulfilment)
Sweeter as us, than you have a right to be
The tongue of vice, a victory of spirits, and solace or lament
Has the voice of harmony, like the very light we seem to eat

Vantage four (escapism)
The terror of repose, that has been divined
Sovereign to forces, with a greater eye, than the silence of despotism
Has reached the known, the curiosity of a simple sigh...

Sign's of the times
Hatred is our reward, no fool without a yesterday
That has, become a terror with us, the saviors of lives
With a solitude we offer is confusion, and the mercy of angels, which may...