Charles Brookfield - 1893
William Gillette - 1899-1930 - 1,300 performances in 30 yrs.
Sherlock Holmes movie Baffled - 1900 Silent/Short - Max Goldberg
John F. Preston - 1900
Charles Rice – 1904
Karoly Baumann - 1905
Maurice Costello - 1905
Viggo Larsen – 1908
Alwin Neub – 1908, 1911, 1914
Otto Lagoni - 1910
Holger Rasmussen – 1911
Mack Sennett – 1911-1912
George Treville - 1912
Harry Benham - 1913
James Bragington - 1914
Francis Ford - 1914
H.A. Saintbury – 1916
Hugo Fink - 1917
Sam Robinson - 1918
Eille Norwood - 1921 Silent short movie - The Dying Detective
Burt Lytell - 1921
Dennis Neillson-Terry - 1921
John Barrymore – 1922
Hamilton Deane – 1923-1932
Tod Slaughter – 1928, 1930
Richard Gordon – 1930-1933, 1936
Clive Brook – 1929/1930/1932
Arthur Wontner – 1931- 1937 – Movie Series
Raymond Massey - 1931
Robert Rendel - 1932
Reginald Owen - 1933
Felix Alymer - 1933
Louis Hector – 1934-1935, 1937
Bruno Guttner – 1937, 1939, 1942-1943
Orson Welles - 1938
Basil Rathbone - 1939-1946
Cedric Hardwick – 1945
Tom Conway – 1947
Howard Marion-Crawford - 1948
John Stanley – 1948-1949
Alan Napier - 1949
Alan Wheatley - 1951
John Longden - 1951
Laidman Browne - 1951
Carleton Hobbs - 1952-1969
Ronald Howard - 1954/55 (39 episodes)
John Gielgud - 1954-1955
Peter Cushing - 1959, 1968, 1984
Christopher Lee - 1962, 1970, 1992
Douglas Wilmer - 1964
John Neville - 1965, 1970, 1978
Robert Stephens - 1970
Stewart Granger – 1972  
John Cleese – 1973
Larry Hagman - 1974
Robert Powell - 1974
Rolf Becker - 1974
John Wood – 1974-1975
Leonard Nimoy - 1976
Douglas Wilmer - 1976
Roger Moore - 1976
Nicol Williamson - 1976
Kevin McCarthy - 1977
Christopher Plummer - 1977
Peter Cook - 1977
Paxton Whitehead - 1978
Barry Foster - 1978
Geoffrey Whitehead - 1979-1980
Graham Armitage - 1979-1980, 1985
Keith Mitchell - 1979
Charlton Heston - 1980
Frank Langella - 1980
Vasily Livanov - Russian T.V. - 1979-1981, 1983 & 1986
John Moffatt - 1981
Guy Henry - 1982
Tom Baker – 1982  
Ian Richardson - 1983
Peter O’Toole – 1983 (animated T.V. films – Australian)
Jeremy Brett - 1984-1994
Nicholas Rowe - 1984
Guy Rolfe – 1984
Dinsdale Landen - 1987
Tim Pigott-Smith – 1987
Anthony Higgins – 1987
Michael Pennington - 1987
Roger Rees - 1988
Ron Moody - 1988-1989
Clive Merrison - 1989-1998, 2002, 2004, 2008-2010
Edward Woodward - 1990
Simon Callow - 1990
Richard E. Grant 1992
Robert Powell – 1993
Patrick McNee – 1993
Anthony Higgins – 1993
1998-2019:  John Gilbert - Episodes 1-18
                     Lawrence Albert - Episode 20
                     John Patrick Lowrie - Episodes 21-65 & 67-until
                     Dennis Bateman - Episode 66
Jason Gray-Stanford – 1999-2001 – Animation
Matt Frewer – 2000-2001
Joaquim de Almeida - 2001
Richard Roxburgh - 2002
James D’Arcy - 2002
Andrew Sachs - 2004
Rupert Everett – 2004
Jonathan Pryce - 2007
Javier Marzan – 2007
Roger Llewellyn – 2009
Robert Downey Jr. 2009 & 2011
Ben Syder – 2010
Nicholas Briggs – 2010-2018
Igor Petrenko - Russian T.V. Series - 2013
Benedict Cumberbatch - 2010-2016
Christian Rode – 2010, 2014
Anthony P.D. Mann - 2011 (More like a thriller "spoof" by V Movies)
Samuel Tady – 2011, 2014, 2017-2018 (Tady Bros. Productions/on YouTube)
Johnny Lee Miller – 2012-2019
Benjamin Lawlor - 2013
Seamus Dever - 2014
Ian McKellen – 2015
Euan Morton – 2015
Gregory Wooddell - 2015
Paul Andrew Goldsmith – 2015-2016
Ewen Bremner - 2016
Jay Taylor – 2017-2018
Yuko Takeuchi – 2018 (HBO Asia – female ‘Holmes’)
Orlando Wells - 2018
Johnny Depp – 2018 (animation)
Will Ferrell – 2018
Nicholas Boulton – 2020
Henry Cavill - 2020
Ethan Bell – 2020 (Fan Film on YouTube)
Ethan Thomas Jung – 2020 Fan Adv.
      (Vagabond Repertory Theater Company—YouTube)

This list is not exhaustive. however, these are some of the
many actors who have played Sherlock Holmes on stage,
screen, radio and T.V. adaptations.